Products
Sample Prep & Detection Kits
Conjugation kitsPurification kitsSample preparation kitsChromogen kitsIHC kitsChIP kitsAccessory Reagents & Controls
Accessory reagents & controlsBiochemicals
BiochemicalsProteins and Peptides
Proteins and peptidesOur latest ELISA kit: Human Tau (phospho T217) - Intracellular
Highly sensitive kit offering the most promising biomarkers for Alzheimer’s disease diagnostics. Learn about all product ranges with our product overviews.
Resources
Featured events
Make new connections at our global events.
Support
Our programs
New Lab Program
Get a head start with our exclusive new lab discount. Enjoy 20% off and free shipping for three months.
New Biotech Program
Just starting out? Get 15% off and free shipping to your lab for six months.
Product promise
Peace of mind that all products perform as stated.
Product reviews
Leave reviews, get rewarded and help your community.
Trial program
Try untested species and applications to earn money off your next order.
Recombinant Human AKR1A1 protein is a Human Full Length protein, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Alternative names=Aldo-keto reductase family 1 member A1, Alcohol dehydrogenase [NADP(+)], Aldehyde reductase, Glucuronate reductase, Glucuronolactone reductase, AKR1A1, ALR, ALDR1
- Purity
>90% SDS-PAGE
- Expression system
Escherichia coli
- Tags
Tag free
- Applications
SDS-PAGE, MS
- Biologically active
No
- Sequence
M A A S C V L L H T G Q K M P L I G L G T W K S E P G Q V K A A V K Y A L S V G Y R H I D C A A I Y G N E P E I G E A L K E D V G P G K A V P R E E L F V T S K L W N T K H H P E D V E P A L R K T L A D L Q L E Y L D L Y L M H W P Y A F E R G D N P F P K N A D G T I C Y D S T H Y K E T W K A L E A L V A K G L V Q A L G L S N F N S R Q I D D I L S V A S V R P A V L Q V E C H P Y L A Q N E L I A H C Q A R G L E V T A Y S P L G S S D R A W R D P D E P V L L E E P V V L A L A E K Y G R S P A Q I L L R W Q V Q R K V I C I P K S I T P S R I L Q N I K V F D F T F S P E E M K Q L N A L N K N W R Y I V P M L T V D G K R V P R D A G H P L Y P F N D P Y
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Images
Recommended products
Recombinant Human AKR1A1 protein is a Human Full Length protein, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Alternative names=Aldo-keto reductase family 1 member A1, Alcohol dehydrogenase [NADP(+)], Aldehyde reductase, Glucuronate reductase, Glucuronolactone reductase, AKR1A1, ALR, ALDR1
Key facts
- Purity
>90% SDS-PAGE
- Expression system
Escherichia coli
- Tags
Tag free
- Applications
SDS-PAGE, MS
- Biologically active
No
- Sequence
M A A S C V L L H T G Q K M P L I G L G T W K S E P G Q V K A A V K Y A L S V G Y R H I D C A A I Y G N E P E I G E A L K E D V G P G K A V P R E E L F V T S K L W N T K H H P E D V E P A L R K T L A D L Q L E Y L D L Y L M H W P Y A F E R G D N P F P K N A D G T I C Y D S T H Y K E T W K A L E A L V A K G L V Q A L G L S N F N S R Q I D D I L S V A S V R P A V L Q V E C H P Y L A Q N E L I A H C Q A R G L E V T A Y S P L G S S D R A W R D P D E P V L L E E P V V L A L A E K Y G R S P A Q I L L R W Q V Q R K V I C I P K S I T P S R I L Q N I K V F D F T F S P E E M K Q L N A L N K N W R Y I V P M L T V D G K R V P R D A G H P L Y P F N D P Y
- Accession
- P14550-1
- Protein length
Full Length
- Animal free
No
- Nature
Recombinant
- Species
Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.29% Sodium chloride
Specifications
- Form
Liquid
- Additional notes
ab95472 was purified using conventional chromatography techniques.
General info
- Function
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed:10510318). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN) (PubMed:18276838, PubMed:11306097). Displays no reductase activity towards retinoids (By similarity).
- Sequence similarities
Belongs to the aldo/keto reductase family.
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com