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AB157875

Recombinant Human ALDH9A1 protein (GST tag N-Terminus)

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Recombinant Human ALDH9A1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 494 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

ALDH4, ALDH7, ALDH9, ALDH9A1, 4-trimethylaminobutyraldehyde dehydrogenase, TMABA-DH, TMABALDH, Aldehyde dehydrogenase E3 isozyme, Aldehyde dehydrogenase family 9 member A1, Formaldehyde dehydrogenase, Gamma-aminobutyraldehyde dehydrogenase, R-aminobutyraldehyde dehydrogenase

1 Images
SDS-PAGE - Recombinant Human ALDH9A1 protein (GST tag N-Terminus) (AB157875)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ALDH9A1 protein (GST tag N-Terminus) (AB157875)

ab157875 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

P49189

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB224360

Anti-ALDH9A1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALDH9A1 antibody (AB224360)

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Cell Lines & Lysates

AB258780

Human ALDH9A1 knockout HEK-293T cell lysate

Sanger Sequencing - Human ALDH9A1 knockout HEK-293T cell lysate (AB258780)

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Cell Lines & Lysates

AB266777

Human ALDH9A1 knockout HEK-293T cell line

Sanger Sequencing - Human ALDH9A1 knockout HEK-293T cell line (AB266777)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVESAF","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":494,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P49189","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ALDH9A1 also known as aldehyde dehydrogenase 9 family member A1 is an enzyme with a molecular mass of approximately 56 kDa. It catalyzes the conversion of aldehydes to carboxylic acids using NAD+ as a cofactor. ALDH9A1 is found in various tissues including the liver brain and kidney where it plays a role in the detoxification processes and metabolism of aldehydes which can be toxic to cells if not properly managed.
Biological function summary

Aldehyde dehydrogenase 9 family member A1 contributes to cellular homeostasis and plays a protective role by processing aldehydes derived from alcohol metabolism and lipid peroxidation. It forms part of the larger aldehyde dehydrogenase family but it does not appear to engage in complex formations with other proteins in any significant manner. ALDH9A1 also assists in the degradation of histidine and proline amino acids that require processing for proper cellular function.

Pathways

ALDH9A1 is significantly involved in the metabolic pathways of amino acids and fatty acids. In these pathways it is closely related to other aldehyde dehydrogenase proteins like ALDH2 which is active in metabolizing acetaldehyde within the alcohol metabolism pathway. Both ALDH9A1 and these proteins help maintain the balance of aldehyde concentrations ensuring no cellular damage occurs due to aldehyde accumulation.

ALDH9A1 has been implicated in neurological conditions such as Parkinson's disease due to its role in preventing aldehyde-induced oxidative stress. Additionally ALDH9A1 may be relevant to certain types of cancers where aldehyde metabolism disrupts normal cellular functions. Interestingly its relation to these diseases often connects it to proteins like ALDH2 which has similar detoxification roles. Understanding its interactions and contributions in these contexts remains an ongoing area of research.
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Specifications

Form

Liquid

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General info

Function

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

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Product protocols

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Target data

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines.
See full target information ALDH9A1
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