Recombinant Human ALF protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ALF also known as Actin-Like Filament is a protein with a molecular mass of approximately 42 kDa. It plays a mechanical role by providing structural support to the cytoskeleton a critical component for maintaining cellular shape and motility. Actin-like proteins are expressed across numerous tissues with a strong presence in muscle cells neurons and endothelial cells. These proteins participate in forming filamentous structures contributing to the integrity and function of cellular architecture.

Biological function summary

This protein facilitates cytoskeletal dynamics and assists in cell division and intracellular transport. ALF operates within a multiprotein complex that includes other actin-related proteins and accessory factors. This assembly coordinates cellular activities that are essential for proper cellular function including cytokinesis and the positioning of organelles. By interacting with other cytoskeletal elements ALF ensures that cells maintain their proper functioning and respond correctly to external stimuli.

Pathways

The actin-like filament participates in the Rho signaling pathway and the Wnt signaling pathway. In these pathways ALF influences cellular activities such as signal transduction and cell polarity. It collaborates closely with proteins like Rac1 and Cdc42 within the Rho signaling network to regulate actin polymerization. Through these interactions ALF helps orchestrate complex cellular functions that are vital for development and homeostasis.

Actin-like filament has links to cardiomyopathies and neurodegenerative diseases. Disruptions in the normal functioning of ALF can lead to structural anomalies in heart tissue contributing to various cardiomyopathies. Additionally deficiencies or mutations in ALF have implications in neurodegenerative conditions where its interaction with proteins like tau can affect neuronal stability. Understanding these relationships can provide insights into the mechanisms underlying these diseases and aid in the development of targeted therapies.