Recombinant Human ALK-7 protein is a Human Full Length protein, in the 1 to 493 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M T R A L C S A L R Q A L L L L A A A A E L S P G L K C V C L L C D S S N F T C Q T E G A C W A S V M L T N G K E Q V I K S C V S L P E L N A Q V F C H S S N N V T K T E C C F T D F C N N I T L H L P T A S P N A P K L G P M E L A I I I T V P V C L L S I A A M L T V W A C Q G R Q C S Y R K K K R P N V E E P L S E C N L V N A G K T L K D L I Y D V T A S G S G S G L P L L V Q R T I A R T I V L Q E I V G K G R F G E V W H G R W C G E D V A V K I F S S R D E R Y W F R E A E I Y Q T V M L R H E N I L G F I A A D N K D N G T W T Q L W L V S E Y H E Q G S L Y D Y L N R N I V T M A G M I K L A L S I A S G L A H L H M E I V G T Q G K P A I A H R D I K S K N I L V K K C E T C A I A D L G L A V K H D S I L N T I D I P Q N P K V G T K R Y M A P E M L D D T M N V N I F E S F K R A D I Y S V G L V Y W E I A R R C S V G G I V E E Y Q L P Y Y D M V P S D P S I E E M R K V V C D Q K F R P S I P N Q W Q S C E A L R V M G R I M R E C W Y A N G A A R L T A L R I K K T I S Q L C V K E D C K A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
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Target data
Function
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Alternative names
ALK7, ACVR1C, Activin receptor type-1C, Activin receptor type IC, Activin receptor-like kinase 7, ACTR-IC, ALK-7
Recommended products
Recombinant Human ALK-7 protein is a Human Full Length protein, in the 1 to 493 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- Q8NER5-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M T R A L C S A L R Q A L L L L A A A A E L S P G L K C V C L L C D S S N F T C Q T E G A C W A S V M L T N G K E Q V I K S C V S L P E L N A Q V F C H S S N N V T K T E C C F T D F C N N I T L H L P T A S P N A P K L G P M E L A I I I T V P V C L L S I A A M L T V W A C Q G R Q C S Y R K K K R P N V E E P L S E C N L V N A G K T L K D L I Y D V T A S G S G S G L P L L V Q R T I A R T I V L Q E I V G K G R F G E V W H G R W C G E D V A V K I F S S R D E R Y W F R E A E I Y Q T V M L R H E N I L G F I A A D N K D N G T W T Q L W L V S E Y H E Q G S L Y D Y L N R N I V T M A G M I K L A L S I A S G L A H L H M E I V G T Q G K P A I A H R D I K S K N I L V K K C E T C A I A D L G L A V K H D S I L N T I D I P Q N P K V G T K R Y M A P E M L D D T M N V N I F E S F K R A D I Y S V G L V Y W E I A R R C S V G G I V E E Y Q L P Y Y D M V P S D P S I E E M R K V V C D Q K F R P S I P N Q W Q S C E A L R V M G R I M R E C W Y A N G A A R L T A L R I K K T I S Q L C V K E D C K A
- Accession
- Q8NER5
- Protein length
- Full Length
- Predicted molecular weight
- 79.97 kDa
- Amino acids
- 1 to 493
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
- Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as Activin A Receptor Type IC.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ALK-7 also known as Activin receptor-like kinase 7 is a type I receptor serine/threonine kinase. It has a molecular mass of approximately 58 kDa. ALK-7 is primarily expressed in the central nervous system pancreatic islets and adipose tissue. This protein plays a mechanical role as a receptor that binds to ligands like Nodal which initiates signaling through phosphorylation events essential for cellular communication and regulation.
- Biological function summary
ALK-7 participates in the regulation of metabolic processes. It functions by forming a receptor complex with type II receptors upon ligand binding transmitting signals that modulate cellular responses. ALK-7's signaling is important in maintaining glucose homeostasis and energy balance within tissues. Additionally the activity of ALK-7 influences the differentiation of neural cells and the development of adipose tissue illustrating its multifaceted biological roles.
- Pathways
The signaling of ALK-7 integrates into the TGF-beta/Activin signaling pathway and the Nodal signaling pathway. Within these pathways it associates functionally with proteins such as SMAD2/3 which facilitate the transmission of extracellular signals to the nucleus resulting in gene expression changes. These pathways are significant for developmental processes and cellular metabolism regulation where ALK-7 contributes to signal transduction necessary for physiological adaptations.
- Associated diseases and disorders
ALK-7 has associations with metabolic syndromes like type 2 diabetes and obesity. Altered ALK-7 signaling affects insulin sensitivity and glucose metabolism linking it to the pathophysiology of these conditions. Furthermore its interaction with Nodal and other factors in related pathways suggests a potential therapeutic target for mitigating metabolic dysfunctions associated with these disorders.
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1 product image
SDS-PAGE - Recombinant Human ALK-7 protein (ab132686)
12.5% SDS-PAGE analysis of ab132686 stained with Coomassie Blue.
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