Recombinant Human Allergin 1 protein (Fc Chimera) is a Human Fragment protein, in the 1 to 227 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Fc tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M W S H L N R L L F W S I F S S V T C R K A V L D C E A M K T N E F P S P C L D S K T K V V M K G Q N V S M F C S H K N K S L Q I T Y S L F R R K T H L G T Q D G K G E P A I F N L S I T E A H E S G P Y K C K A Q V T S C S K Y S R D F S F T I V D P V T S P V L N I M V I Q T E T D R H I T L H C L S V N G S L P I N Y T F F E N H V A I S P A I S K Y D R E P A E F N L T K K N P G E E E E Y R C E A K N R L P N Y A T Y S H P V T M P S T G G D S C P F C L K
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).
Alternative names
C17orf60, MCA32, MILR1, Allergin-1, Allergy inhibitory receptor 1, Mast cell antigen 32, Mast cell immunoglobulin-like receptor 1, MCA-32
Recommended products
Recombinant Human Allergin 1 protein (Fc Chimera) is a Human Fragment protein, in the 1 to 227 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Fc tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q7Z6M3-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M W S H L N R L L F W S I F S S V T C R K A V L D C E A M K T N E F P S P C L D S K T K V V M K G Q N V S M F C S H K N K S L Q I T Y S L F R R K T H L G T Q D G K G E P A I F N L S I T E A H E S G P Y K C K A Q V T S C S K Y S R D F S F T I V D P V T S P V L N I M V I Q T E T D R H I T L H C L S V N G S L P I N Y T F F E N H V A I S P A I S K Y D R E P A E F N L T K K N P G E E E E Y R C E A K N R L P N Y A T Y S H P V T M P S T G G D S C P F C L K
- Accession
- Q7Z6M3
- Protein length
- Fragment
- Predicted molecular weight
- 50.1 kDa
- Amino acids
- 1 to 227
- Nature
- Recombinant
- Tags
- Fc tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).
- Post-translational modifications
N-glycosylated.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Allergin-1 also known as allergine or epityphlon is a membrane protein expressed in myeloid cells particularly mast cells and basophils. The protein has a mass of approximately 50 kDa. Allergin-1 plays a role in signaling processes that regulate immune responses especially those involving allergen recognition and response. This protein contributes to modulating the activation and deactivation of these immune cells helping maintain a balanced immune reaction.
- Biological function summary
Allergin-1 functions as an inhibitory receptor on myeloid cells. It forms part of a complex with other signaling proteins to suppress excessive immune responses that can lead to allergic reactions. This modulation involves interacting with several intracellular signaling proteins which in turn influence the release of mediators that affect the immune response. Allergin-1 through its inhibitory actions helps prevent over-activation of immune pathways that can contribute to allergic inflammation.
- Pathways
Allergin-1 is involved in immune regulatory pathways such as the Fc receptor signaling pathway. It interacts with proteins like Syk kinase and SH2-containing phosphatases contributing to the negative regulation of cell activation. These pathways are key in the immune system's ability to distinguish between harmful and benign stimuli playing a protective role against unwarranted inflammatory responses.
- Associated diseases and disorders
Allergin-1 has connections to allergic conditions such as asthma and atopic dermatitis. Allergin-1's ability to modulate immune cell activation can influence the severity and occurrence of these allergic diseases. The protein’s interaction with other immune regulators such as SHIP1 demonstrates its importance in managing diseases where exaggerated immune responses occur. Understanding these connections is essential for developing therapeutic strategies aimed at treating allergic disorders.
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1 product image
SDS-PAGE - Recombinant Human Allergin 1 protein (Fc Chimera) (ab276719)
SDS-PAGE analysis of ab276719
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