Recombinant Human Alpha 1 Acid Glycoprotein/AGP (denatured) is a Human Full Length protein, in the 19 to 201 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M Q I P L C A N L V P V P I T N A T L D Q I T G K W F Y I A S A F R N E E Y N K S V Q E I Q A T F F Y F T P N K T E D T I F L R E Y Q T R Q D Q C I Y N T T Y L N V Q R E N G T I S R Y V G G Q E H F A H L L I L R D T K T Y M L A F D V N D E K N W G L S V Y A D K P E T T K E Q L G E F Y E A L D C L R I P K S D V V Y T D W K K D K C E P L E K Q H E K E R K Q E E G E S
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Functions as a transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Alternative names
AGP1, ORM1, Alpha-1-acid glycoprotein 1, AGP 1, Orosomucoid-1, OMD 1
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Recombinant Human Alpha 1 Acid Glycoprotein/AGP (denatured) is a Human Full Length protein, in the 19 to 201 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P02763-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 5% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl
Sequence info
Amino acid sequence
- M Q I P L C A N L V P V P I T N A T L D Q I T G K W F Y I A S A F R N E E Y N K S V Q E I Q A T F F Y F T P N K T E D T I F L R E Y Q T R Q D Q C I Y N T T Y L N V Q R E N G T I S R Y V G G Q E H F A H L L I L R D T K T Y M L A F D V N D E K N W G L S V Y A D K P E T T K E Q L G E F Y E A L D C L R I P K S D V V Y T D W K K D K C E P L E K Q H E K E R K Q E E G E S
- Accession
- P02763
- Protein length
- Full Length
- Predicted molecular weight
- 21.7 kDa
- Amino acids
- 19 to 201
- Nature
- Recombinant
Specifications
- Form
- Liquid
- Additional notes
ab109931 is purified using conventional chromatography techniques.
General info
- Function
Functions as a transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
- Sequence similarities
Belongs to the calycin superfamily. Lipocalin family.
- Post-translational modifications
N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Alpha 1 Acid Glycoprotein also known as AGP or Alpha 1 Glycoprotein is a plasma protein with a molecular weight of approximately 41 to 43 kDa. This protein circulates primarily in the bloodstream and is produced mainly by the liver. AGP is known for its highly glycosylated structure carrying several branched oligosaccharide chains. It exhibits a significant capacity to bind various endogenous and exogenous lipophilic substances influencing their transport and distribution in the body.
- Biological function summary
AGP plays a role in modulating the immune response and maintaining homeostasis. As an acute-phase protein its levels rise significantly during inflammation infection and trauma where it acts to modulate the immune system. AGP does not exist as part of a larger protein complex but interacts with plasma lipoproteins and other glycoproteins aiding in its function of maintaining vascular integrity during acute-phase reactions.
- Pathways
Alpha 1 Glycoprotein serves as an important component in the inflammatory response and drug-binding pathways. In the inflammatory pathway AGP interacts with cytokines and acute-phase reactants adjusting the body’s inflammatory processes. It is also involved in the binding and distribution of drugs interacting with albumin and other transport proteins to influence the pharmacokinetics of many medications.
- Associated diseases and disorders
AGP levels change in response to conditions like rheumatoid arthritis and liver diseases. In rheumatoid arthritis its increased levels correlate with disease activity and inflammation. In liver diseases the production and plasma concentration of AGP can reflect hepatic synthesis capability. AGP's interaction with cytokines in these conditions often links it to elevated levels of other acute-phase proteins like C-reactive protein reflecting its participation in the pathophysiological processes of inflammation.
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1 product image
SDS-PAGE - Recombinant Human Alpha 1 Acid Glycoprotein/AGP (denatured) (ab109931)
15% SDS-PAGE showing ab109931 at approximately 21.7kDa (3µg).
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