Recombinant human alpha Defensin 1 protein is a Human Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, FuncS.
A C Y C R I P A C I A G E R R Y G T C I Y Q G R L W A F C C
| Application | Reactivity | Dilution info | Notes |
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Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses or by promoting the activation and maturation of some APCs (PubMed:15616305, PubMed:17142766, PubMed:20220136, PubMed:24236072). Interacts with the essential precursor of cell wall synthesis lipid II to inhibit bacterial cell wall synthesis (PubMed:20214904). Inhibits adenovirus infection via inhibition of viral disassembly at the vertex region, thereby restricting the release of internal capsid protein pVI, which is required for endosomal membrane penetration during cell entry (PubMed:18191790). In addition, interaction with adenovirus capsid leads to the redirection of viral particles to TLR4 thereby promoting a NLRP3-mediated inflammasome response and interleukin 1-beta (IL-1beta) release (PubMed:35080426). Induces the production of proinflammatory cytokines including type I interferon (IFN) in plasmacytoid dendritic cells (pDCs) by triggering the degradation of NFKBIA and nuclear translocation of IRF1, both of which are required for activation of pDCs (PubMed:27031443).
DEF1, DEFA2, MRS, DEFA1B, DEFA1, Neutrophil defensin 1, HNP-1, HP-1, HP1
Recombinant human alpha Defensin 1 protein is a Human Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, FuncS.
Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses or by promoting the activation and maturation of some APCs (PubMed:15616305, PubMed:17142766, PubMed:20220136, PubMed:24236072). Interacts with the essential precursor of cell wall synthesis lipid II to inhibit bacterial cell wall synthesis (PubMed:20214904). Inhibits adenovirus infection via inhibition of viral disassembly at the vertex region, thereby restricting the release of internal capsid protein pVI, which is required for endosomal membrane penetration during cell entry (PubMed:18191790). In addition, interaction with adenovirus capsid leads to the redirection of viral particles to TLR4 thereby promoting a NLRP3-mediated inflammasome response and interleukin 1-beta (IL-1beta) release (PubMed:35080426). Induces the production of proinflammatory cytokines including type I interferon (IFN) in plasmacytoid dendritic cells (pDCs) by triggering the degradation of NFKBIA and nuclear translocation of IRF1, both of which are required for activation of pDCs (PubMed:27031443).
Belongs to the alpha-defensin family.
ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Alpha defensin 1 also known as human defensin 1 or neutrophil defensin 1 is a small cationic peptide with a mass of approximately 3-4 kDa. This protein is mainly expressed in neutrophils where it plays an essential role in the body's innate immune system. Additional sites of expression include Paneth cells in the intestines where alpha defensins contribute to mucosal immunity. Its structure consists of three intramolecular disulfide bonds that confer stability and enable its antimicrobial properties.
The alpha defensin 1 peptide disrupts the integrity of microbial membranes by inserting into microbial lipid bilayers leading to membrane permeabilization and lysis. This activity is not limited to bacteria; it also affects fungi and some viruses. The peptide is not part of a complex but it acts as a standalone antimicrobial agent. Besides its antimicrobial role alpha defensin 1 can modulate inflammatory responses and influence wound healing. It interacts with chemokines and cytokines affecting immune modulation.
Alpha defensin 1 is integral to the antimicrobial response pathway and innate immunity processes. In the antimicrobial defense pathway it collaborates with other defensins and lysozymes to ensure pathogen elimination. In the innate immunity processes it works in conjunction with cytokines such as IL-8 which recruits more neutrophils to infection sites. Both pathways highlight alpha defensin 1's importance in both direct defense mechanisms and immune signaling.
Alpha defensin 1 is linked to inflammatory conditions and autoimmune diseases such as Crohn’s disease and ulcerative colitis. In Crohn's disease altered levels of alpha defensin 1 relate to intestinal inflammation and microbial imbalance. It is also connected to rheumatoid arthritis where its role in inflammation may exacerbate disease activity. In these conditions alpha defensin 1 interacts with other proteins including TNF-alpha an important cytokine involved in inflammatory pathways.
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