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AB185380

Recombinant Human Alpha Taxilin protein

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Recombinant Human Alpha Taxilin protein is a Human Fragment protein, in the 1 to 162 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

TXLN, TXLNA, Alpha-taxilin

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

His tag C-Terminus His tag N-Terminus

Applications

HPLC, SDS-PAGE

applications

Biologically active

No

Accession

P40222

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 3X PBS.

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMKNQDKKNGAAKQSNPKSSPGQPEAGPEGAQERPSQAAPAVEAEGPGSSQAPRKPEGAQARTAQSGALRDVSEELSRQLEDILSTYCVDNNQGGPGEDGAQGEPAEPEDAEKSRTYVARNGEPEPTPVVNGEKEPSKGDPNTEEIRQSDEVGDRDHRRPQEKLEHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"20.45 kDa","actualMolecularWeight":null,"aminoAcidEnd":162,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P40222","tags":[{"tag":"His","terminus":"C-Terminus"},{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Alpha Taxilin also known as TXLNA taxilin alpha or IL8RA binding protein is a protein with a molecular mass of about 49 kDa. It plays a role in intracellular transport processes including vesicle fusion. Primarily expressed in the brain Alpha Taxilin interacts with membranes and cytoskeletal elements to facilitate cargo and organelle movement. Its presence in other tissues such as the placenta suggests additional roles beyond neural activities.
Biological function summary

This protein mediates protein trafficking and membrane dynamics within cells. Alpha Taxilin forms part of a complex involving several SNARE proteins like syntaxins which are essential for vesicle docking and fusion. By participating in these interactions Alpha Taxilin aids in maintaining cellular homeostasis and supporting signal transduction processes.

Pathways

Alpha Taxilin plays a role in intracellular signaling and vesicular transport processes influencing pathways such as neurotransmitter release and hormone secretion. It associates with other proteins like syntaxin 1 contributing to the protein sorting and vesicular trafficking pathway. These pathways are integral to maintaining cellular communication and proper distribution of signaling molecules.

Alpha Taxilin associates with neurodevelopmental and neurodegenerative conditions. Abnormal expression levels or mutations can contribute to disorders such as schizophrenia and Alzheimer's disease. Through its interaction with SNARE proteins particularly syntaxin 1 Alpha Taxilin influences processes that when disrupted may lead to synaptic dysfunction emphasizing its potential role in nervous system disorders.
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Specifications

Form

Lyophilized

Additional notes

Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

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General info

Function

May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.

Sequence similarities

Belongs to the taxilin family.

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Product protocols

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Target data

May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.
See full target information TXLNA
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