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AB137137

Recombinant Human Amelotin protein (His tag N-Terminus)

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Recombinant Human Amelotin protein (His tag N-Terminus) is a Human Full Length protein, in the 17 to 209 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

UNQ689/PRO1329, AMTN, Amelotin

1 Images
SDS-PAGE - Recombinant Human Amelotin protein (His tag N-Terminus) (AB137137)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Amelotin protein (His tag N-Terminus) (AB137137)

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q6UX39

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSLPQLKPALGLPPTKLAPDQGTLPNQQQSNQVFPSLSLIPLTQMLTLGPDLHLLNPAAGMTPGTQTHPLTLGGLNVQQQLHPHVLPIFVTQLGAQGTILSSEELPQIFTSLIIHSLFPGGILPTSQAGANPDVQDGSLPAGGAGVNPATQGTPAGRLPTPSGTDDDFAVTTPAGIQRSTHAIEEATTESANGIQ","proteinLength":"Full Length","predictedMolecularWeight":"22.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":209,"aminoAcidStart":17,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q6UX39","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Amelotin also known as AMTN is a protein involved in the formation and mineralization of dental enamel. The protein has an estimated mass of approximately 24 kilodaltons. It is expressed in high amounts in ameloblasts which are cells involved in dental enamel production especially in the maturation stage of enamel development.
Biological function summary

The protein encoded by the Amelotin gene plays a significant role in dental epithelial cell differentiation and enamel biomineralization. Amelotin does not appear to form part of a larger protein complex but acts in coordination with other enamel matrix proteins. Its expression increases as ameloblasts transition into maturation stage suggesting it modulates enamel matrix mineralization.

Pathways

The protein influences tooth development processes particularly within the amelogenesis pathway. Amelotin interacts with and complements the roles of other enamel matrix proteins such as amelogenin and enamelin. Its activity contributes to the regulation of calcium and phosphate ion deposition required for enamel hardening.

Malfunction or altered expression of Amelotin associates with amelogenesis imperfecta a disorder affecting enamel development. The interaction between Amelotin and enamelin may be important in understanding the pathophysiology of this condition. It is also implicated in carious lesions due to its potential impact on enamel resilience. Understanding Amelotin's function can offer insights into these dental health issues and point to therapeutic interventions.
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Specifications

Form

Liquid

Additional notes

ab137137 is purified using conventional chromatography techniques.

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General info

Function

Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.

Sequence similarities

Belongs to the amelotin family.

Post-translational modifications

Phosphorylated by FAM20C in vitro.. O-glycosylated.

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Product protocols

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Target data

Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.
See full target information AMTN
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Complementary Products

Primary Antibodies

AB122312

Anti-Amelotin antibody

Immunocytochemistry/ Immunofluorescence - Anti-Amelotin antibody (AB122312)

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