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AB183235

Recombinant Human Amisyn protein

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Recombinant Human Amisyn protein is a Human Full Length protein, in the 1 to 210 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

HSPC156, STXBP6, Syntaxin-binding protein 6, Amisyn

1 Images
SDS-PAGE - Recombinant Human Amisyn protein (AB183235)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Amisyn protein (AB183235)

15% SDS-PAGE analysis of ab183235 (3μg)

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q8NFX7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMSAKSAISKEIFAPLDERMLGAVQVKRRTKKKIPFLATGGQGEYLTYICLSVTNKKPTQASITKVKQFEGSTSFVRRSQWMLEQLRQVNGIDPNGDSAEFDLLFENAFDQWVASTASEKCTFFQILHHTCQRYLTDRKPEFINCQSKIMGGNSILHSAADSVTSAVQKASQALNERGERLGRAEEKTEDLKNSAQQFAETAHKLAMKHKC","proteinLength":"Full Length","predictedMolecularWeight":"26 kDa","actualMolecularWeight":null,"aminoAcidEnd":210,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8NFX7","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Amisyn also known by its alternate name TRIM3 is a small protein with a molecular mass of approximately 25 kDa. It is expressed in various tissues including the brain where it plays a significant role in neuronal function. Mechanically Amisyn functions as a member of the TRIM family proteins which have E3 ubiquitin ligase activity. This activity enables Amisyn to regulate protein degradation through ubiquitination.
Biological function summary

Amisyn contributes to cellular homeostasis and maintains proteostasis. It is involved in the formation of protein complexes that are important for cellular signaling and protein turnover. As part of a ubiquitin ligase complex Amisyn targets specific proteins for degradation which helps maintain cellular protein levels balanced. This control mechanism affects critical cellular processes such as cell cycle progression and apoptosis.

Pathways

Researchers have identified that Amisyn integrates into the ubiquitin-proteasome system and is linked to the autophagy pathway. It interacts biologically with proteins such as ubiquitin and p62 which are part of the autophagic machinery. The involvement of Amisyn in the degradation of misfolded proteins and the regulation of autophagy outlines its role in cellular maintenance and nutrient sensing pathways.

Disruptions in Amisyn expression or function have connections to neurodegenerative diseases particularly Alzheimer's disease. Amisyn has been associated with proteins involved in Alzheimer's such as amyloid precursor protein (APP) and tau influencing protein aggregation and degradation. Additionally Amisyn dysregulation may relate to certain cancers by impacting cell proliferation and apoptosis pathways. Its association with the disruption of tumor suppressor pathways suggests a role in oncogenesis.
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Specifications

Form

Liquid

Additional notes

ab183235 was purified using conventional chromatography.

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General info

Function

Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.

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Product protocols

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Target data

Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis.
See full target information STXBP6
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Product promise

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