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AB139248

Recombinant Human AMN protein

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(1 Publication)

Recombinant Human AMN protein is a Human Fragment protein, in the 20 to 357 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

UNQ513/PRO1028, AMN, Protein amnionless

1 Images
SDS-PAGE - Recombinant Human AMN protein (AB139248)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human AMN protein (AB139248)

15% SDS-PAGE analysis of 3 µg ab139248.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9BXJ7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSVSKLWVPNTDFDVAANWSQNRTPCAGGAVEFPADKMVSVLVQEGHAVSDMLLPLDGELVLASGAGFGVSDVGSHLDCGAGEPAVFRDSDRFSWHDPHLWRSGDEAPGLFFVDAERVPCRHDDVFFPPSASFRVGLGPGASPVRVRSISALGRTFTRDEDLAVFLASRAGRLRFHGPGALSVGPEDCADPSGCVCGNAEAQPWICAALLQPLGGRCPQAACHSALRPQGQCCDLCGAVVLLTHGPAFDLERYRARILDTFLGLPQYHGLQVAVSKVPRSSRLREADTEIQVVLVENGPETGGAGRLARALLADVAENGEALGVLEATMRESGAHVWGSS","proteinLength":"Fragment","predictedMolecularWeight":"38.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":357,"aminoAcidStart":20,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BXJ7","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Specifications

Form

Liquid

Additional notes

ab139248 is purified using conventional chromatography techniques.

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General info

Function

Membrane-bound component of the endocytic receptor formed by AMN and CUBN (PubMed : 14576052, PubMed : 29402915, PubMed : 30523278). Required for normal CUBN glycosylation and trafficking to the cell surface (PubMed : 14576052, PubMed : 29402915). The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12 (PubMed : 12590260, PubMed : 14576052, PubMed : 26040326). Required for normal CUBN-mediated protein transport in the kidney (Probable).

Post-translational modifications

N-glycosylated.. A soluble form arises by proteolytic removal of the membrane anchor.

Subcellular localisation

Endosome membrane

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Product protocols

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Target data

Membrane-bound component of the endocytic receptor formed by AMN and CUBN (PubMed : 14576052, PubMed : 29402915, PubMed : 30523278). Required for normal CUBN glycosylation and trafficking to the cell surface (PubMed : 14576052, PubMed : 29402915). The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12 (PubMed : 12590260, PubMed : 14576052, PubMed : 26040326). Required for normal CUBN-mediated protein transport in the kidney (Probable).
See full target information AMN
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 19:e0296024 PubMed38206981

2024

Expression of the cobalamin transporters cubam and MRP1 in the canine ileum-Upregulation in chronic inflammatory enteropathy.

Applications

Unspecified application

Species

Unspecified reactive species

Stefanie Kather,Johannes Kacza,Helga Pfannkuche,Denny Böttcher,Chi-Hsuan Sung,Joerg M Steiner,Gotthold Gäbel,Franziska Dengler,Romy M Heilmann
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Primary Antibodies

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Primary Antibodies

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