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AB178461

Recombinant Human ANGPTL2/ARP2 protein - BSA and Azide free

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Recombinant Human ANGPTL2/ARP2 protein - BSA and Azide free is a Human Full Length protein, in the 23 to 493 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, ELISA, WB, Mass Spec.

View Alternative Names

ARP2, UNQ170/PRO196, ANGPTL2, Angiopoietin-related protein 2, Angiopoietin-like protein 2

Key facts

Purity

>95% Densitometry

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, WB, ELISA, Mass Spec

applications

Biologically active

No

Accession

Q9UKU9

Animal free

No

Carrier free

Yes

Species

Human

Reconstitution

Reconstitute in 200 µL of water

Storage buffer

Constituents: 2.5% Acetate buffer

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as ANGPTL2
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Sequence info

[{"sequence":"MKHHHHHHASQEDGFEGTEEGSPREFIYLNRYKRAGESQDKCTYTFIVPQQRVTGAICVNSKEPEVLLENRVHKQELELLNNELLKQKRQIETLQQLVEVDGGIVSEVKLLRKESRNMNSRVTQLYMQLLHEIIRKRDNALELSQLENRILNQTADMLQLASKYKDLEHKYQHLATLAHNQSEIIAQLEEHCQRVPSARPVPQPPPAAPPRVYQPPTYNRIINQISTNEIQSDQNLKVLPPPLPTMPTLTSLPSSTDKPSGPWRDCLQALEDGHDTSSIYLVKPENTNRLMQVWCDQRHDPGGWTVIQRRLDGSVNFFRNWETYKQGFGNIDGEYWLGLENIYWLTNQGNYKLLVTMEDWSGRKVFAEYASFRLEPESEYYKLRLGRYHGNAGDSFTWHNGKQFTTLDRDHDVYTGNCAHYQKGGWWYNACAHSNLNGVWYRGGHYRSRYQDGVYWAEFRGGSYSLKKVVMMIRPNPNTFH","proteinLength":"Full Length","predictedMolecularWeight":"58 kDa","actualMolecularWeight":null,"aminoAcidEnd":493,"aminoAcidStart":23,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9UKU9","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate long-term storage conditions
-80°C
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ANGPTL2 protein also known as angiopoietin-like 2 or ARP2 is a secreted glycoprotein involved in various physiological processes. It weighs approximately 56 kDa. ANGPTL2 is expressed in several tissues including the heart lungs and adipose tissues indicating its diverse regulatory roles in the body. Researchers have identified its ability to modulate both local and systemic actions which highlights its significance in health and disease.
Biological function summary

ANGPTL2 plays a role in regulating angiogenesis inflammation and metabolic pathways. It acts independently and is not considered part of a larger complex. The protein demonstrates the ability to stimulate endothelial cell migration and proliferation promoting new blood vessel formation. Furthermore ANGPTL2 influences inflammatory responses and lipid metabolism linking it to energy balance and homeostasis functions within the organism.

Pathways

ANGPTL2 is significant in both the angiogenesis and inflammatory signaling pathways. In angiogenesis it interacts with pathways related to vascular endothelial growth factor (VEGF) which plays a critical role in blood vessel formation. In inflammatory signaling ANGPTL2 links to the nuclear factor kappa B (NF-kB) pathway which is essential for regulating immune responses. These associations position ANGPTL2 as an important influencer in cardiovascular health and immune system regulation.

ANGPTL2 has associations with chronic inflammatory diseases and cancer. Studies have indicated high levels of this protein in conditions like rheumatoid arthritis contributing to persistent inflammation. Furthermore elevated ANGPTL2 expression links to various cancers influencing tumor growth and metastasis. Its activity has connections with proteins like IL-6 and VEGF which are involved in the inflammatory and angiogenic processes respectively marking ANGPTL2 as a potential target for therapeutic intervention.
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Specifications

Form

Lyophilized

Additional notes

ab178461 is purifed using Ni-NTA chromatography and filtered (0.4 µm).

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General info

Function

Induces sprouting in endothelial cells through an autocrine and paracrine action.

Post-translational modifications

N-glycosylated.

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Product protocols

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Target data

Induces sprouting in endothelial cells through an autocrine and paracrine action.
See full target information ANGPTL2
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