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AB109158

Recombinant human ANGPTL7 protein

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Recombinant human ANGPTL7 protein is a Human Full Length protein, in the 1 to 346 aa range, expressed in HEK 293 cells, with >90%, < 0.1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.

View Alternative Names

CDT6, UNQ313/PRO356, ANGPTL7, Angiopoietin-related protein 7, Angiopoietin-like factor, Angiopoietin-like protein 7, Cornea-derived transcript 6 protein

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 0.1 EU/µg

Expression system

HEK 293 cells

Tags

DDDDK tag C-Terminus

Applications

FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

Activates ERK phosphorylation in THP1 cells.

Accession

O43827

Animal free

No

Carrier free

Yes

Species

Human

Storage buffer

Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" } } }
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Sequence info

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":"45 kDa","actualMolecularWeight":null,"aminoAcidEnd":346,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"O43827","tags":[{"tag":"DDDDK","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ANGPTL7 protein also known as Angiopoietin-like 7 plays a role in mechanistic processes. It has a molecular mass of about 45 kDa. ANGPTL7 is expressed primarily in the cornea and trabecular meshwork of the eye but it is also found in other tissues like the liver and heart. This protein is part of the larger angiopoietin-like protein family which is involved in numerous functions related to angiogenesis and metabolism.
Biological function summary

ANGPTL7 participates in the regulation of extracellular matrix composition and collagen deposition affecting tissue remodeling. It does not form a known complex with other molecules but influences the structural integrity of tissues through its regulatory actions. ANGPTL7 potentially interacts with cellular receptors to mediate these effects contributing to maintenance and repair of tissue structures.

Pathways

ANGPTL7 interacts within the framework of the TGF-beta signaling pathway influencing cellular growth and differentiation. Another important pathway involving ANGPTL7 is the Wnt signaling cascade which is important for various developmental processes. In these pathways ANGPTL7 has functional interactions with proteins such as TGF-beta and beta-catenin modulating their activity and impact on cellular functions.

ANGPTL7 has connections to ocular diseases like glaucoma where its expression levels alter the outflow facility of aqueous humor. It also relates to fibrosis since the regulation of collagen deposition is an important factor. The involvement of ANGPTL7 in these conditions links it with proteins such as myocilin in glaucoma and TIMP-1 in fibrosis highlighting its role in pathological tissue remodeling.
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Specifications

Form

Liquid

Additional notes

ab109158 is an 0.2 µm filtered solution.

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General info

Function

Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (PubMed : 21199193). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed : 25622036).

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Product protocols

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Target data

Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (PubMed : 21199193). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed : 25622036).
See full target information ANGPTL7
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