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AB162876

Recombinant Human ANKHD1 protein (GST tag N-Terminus)

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Recombinant Human ANKHD1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 627 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

KIAA1085, MASK, VBARP, PP2500, ANKHD1, Ankyrin repeat and KH domain-containing protein 1, HIV-1 Vpr-binding ankyrin repeat protein, Multiple ankyrin repeats single KH domain, hMASK

1 Images
SDS-PAGE - Recombinant Human ANKHD1 protein (GST tag N-Terminus) (AB162876)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ANKHD1 protein (GST tag N-Terminus) (AB162876)

ab162876 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q8IWZ3

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Proteins & Peptides

AB159808

Recombinant Human ZAN protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZAN protein (GST tag N-Terminus) (AB159808)

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Primary Antibodies

AB117788

Anti-ANKHD1 antibody

Immunoprecipitation - Anti-ANKHD1 antibody (AB117788)

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  • 0
Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

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Proteins & Peptides

AB161165

Recombinant Human WASF3 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human WASF3 protein (GST tag N-Terminus) (AB161165)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MLTDSGGGGTSFEEDLDSVAPRSAPAGASEPPPPGGVGLGIRTVRLFGEAGPASGVGSSGGGGSGSGTGGGDAALDFKLAAAVLRTGGGGGASGSDEDEVSEVESFILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMKTILEGIDPAKHQVRVAFDACKLLRKE","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":627,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8IWZ3","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ANKHD1 or Ankyrin Repeat and KH Domain Containing 1 is a protein characterized by the presence of ankyrin repeats and KH domains which suggest its role in protein-protein and protein-RNA interactions. The molecular mass of ANKHD1 is approximately 278 kDa. This protein is widely expressed in various tissues with significant presence observed in the brain liver and kidney. Its structural domains facilitate binding which indicates a potential regulatory function in cellular mechanisms.
Biological function summary

ANKHD1 participates in cellular proliferation and differentiation processes. While it is not solely part of a larger protein complex its interaction with other proteins hints at its role in signal transduction pathways. ANKHD1 interacts with molecules involved in these processes influencing gene expression and cell dynamics which are critical for normal cellular functions and adaptation to stimuli. This protein modulates various signaling cascades which can have broad implications within the cell.

Pathways

ANKHD1 interacts with key signaling pathways notably the PI3K/AKT and Wnt pathways. These pathways are essential for cell growth survival and differentiation. In the PI3K/AKT pathway ANKHD1 can affect the phosphorylation state of proteins altering downstream signal cascades. It also associates with proteins such as β-catenin in the Wnt pathway controlling transcriptional activities that influence cell fate and proliferation. The integration in these pathways underlines its significance in maintaining cellular homeostasis and response.

Researchers have linked ANKHD1 to cancer particularly leukemia and breast cancer. Its involvement in proliferative signaling makes it a candidate for oncogenic processes. ANKHD1 overexpression has been observed in cancerous tissues suggesting its potential role in tumorigenesis. In leukemia its interaction with other oncogenes like BCR-ABL may exacerbate disease progression. Similarly its role in cell survival pathways through relations with proteins like AKT highlightd its impact in cancer biology offering potential targets for therapeutic interventions.
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Specifications

Form

Liquid

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General info

Function

May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases.

Sequence similarities

Belongs to the mask family.

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Product protocols

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Target data

May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases.
See full target information ANKHD1
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