Recombinant Human ANKRA2 protein (His tag N-Terminus)
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Recombinant Human ANKRA2 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 313 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
ANKRA, ANKRA2, Ankyrin repeat family A protein 2, RFXANK-like protein 2
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human ANKRA2 protein (His tag N-Terminus) (AB183225)
15% SDS-PAGE analysis of ab183225 (3μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ANKRA2 associates with other protein structures to form complexes integral to cellular operations. It contributes to the regulation of gene expression and intracellular signaling processes. Within the nucleus ANKRA2 interacts with transcription regulatory complexes playing a role in modifying the transcription activity. This interaction allows it to contribute to the fine-tuning of gene activity affecting cell growth and differentiation.
Pathways
ANKRA2 finds itself in connection with the Notch signaling and NF-κB pathways both important for various cellular functions. In the Notch signaling pathway ANKRA2 directly interacts with Notch receptors to modulate target gene expression. Additionally within the NF-κB pathway ANKRA2 influences the activation of NF-κB transcription factors which are vital for immune response and inflammation. Its engagement with these pathways highlights its role as a modulator in signal transduction processes.
Specifications
Form
Liquid
Additional notes
ab183225 was purified using conventional chromatography techniques.
General info
Function
May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed : 25752541). May also regulate LRP2/megalin (By similarity).
Subcellular localisation
Cytoskeleton
Target data
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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