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AB134543

Recombinant Human ANKRD1 protein

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(1 Publication)

Recombinant Human ANKRD1 protein is a Human Full Length protein, in the 1 to 319 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C193, CARP, HA1A2, ANKRD1, Ankyrin repeat domain-containing protein 1, Cardiac ankyrin repeat protein, Cytokine-inducible gene C-193 protein, Cytokine-inducible nuclear protein

1 Images
SDS-PAGE - Recombinant Human ANKRD1 protein (AB134543)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ANKRD1 protein (AB134543)

15% SDS-PAGE analysis of 3 μg ab134543.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q15327

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8.5 Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.08% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMMVLKVEELVTGKKNGNGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSRIATF","proteinLength":"Full Length","predictedMolecularWeight":"38.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":319,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q15327","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ANKRD1 also known as Ankyrin Repeat Domain 1 or CARP (Cardiac Ankyrin Repeat Protein) is a protein with a molecular weight of approximately 39 kDa. It is involved in cellular mechanics and is widely expressed in heart skeletal muscle and kidney tissues. ANKRD1 functions as a nuclear transcription factor and also binds to other cytoskeletal proteins influencing structural organization and cellular dynamics. Its presence is significant in muscle cells where it participates in responding to mechanical stress.
Biological function summary

ANKRD1 plays a role in the regulation of gene expression especially in the cardiovascular system. It interacts with muscle structural proteins and can form part of a complex with titin which is a giant protein essential for muscle flexibility and elasticity. ANKRD1 modulates muscle development and function by affecting the expression of genes linked to muscle growth and repair. It responds to mechanical stretch in muscles influencing transcriptional activity linked to adaptation and stress resistance.

Pathways

ANKRD1 is involved in the cardiac hypertrophy and muscle cell stress response pathways where its role in these processes is well documented. It interacts with proteins such as p53 contributing to pathways that manage cellular stress and damage response. ANKRD1 participates in signaling events that modify cardiovascular cell growth and survival and this involvement makes it significant in understanding cardiac remodeling and hypertrophic processes.

ANKRD1 is relevant to cardiomyopathy and muscular dystrophy. Abnormal expression or mutations in the ANKRD1 gene are linked to cardiomyopathy a disease where heart muscle becomes thick or weak. It has associations with other muscle regulatory proteins including dystrophin which plays a role in muscle integrity and is implicated in muscular dystrophy. These connections highlight ANKRD1’s importance in both normal cardiac function and in the pathogenesis of heart and muscle diseases.
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Specifications

Form

Liquid

Additional notes

ab134543 is purified using conventional chromatography techniques.

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General info

Function

May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.

Subcellular localisation

Nucleus

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Product protocols

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Target data

May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.
See full target information ANKRD1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

ACS nano 16:10163-10178 PubMed35617518

2022

Down-Regulating Scar Formation by Microneedles Directly a Mechanical Communication Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Qing Zhang,Lin Shi,Hong He,Xingmou Liu,Yong Huang,Dan Xu,Mengyun Yao,Ning Zhang,Yicheng Guo,Yifei Lu,Haisheng Li,Junyi Zhou,Jianglin Tan,Malcolm Xing,Gaoxing Luo
View all publications
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