Recombinant Human ANKRD50 protein (His-DHFR tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ANKRD50 also known as Ankyrin Repeat Domain 50 is a protein that plays an important mechanical role within cells. It is a large protein with a molecular weight approximately 203 kDa and is expressed in various tissues including muscle and brain. ANKRD50 contains multiple ankyrin repeat motifs which are protein-protein interaction domains that enable it to interact with other proteins effectively.

Biological function summary

The functionality of this protein is associated with important cellular processes. ANKRD50 is involved in protein stabilization and transport within the cell. It is part of a larger protein complex that helps coordinate these processes particularly in maintaining cellular homeostasis and organization. Its role in these functions suggests that it may have broader implications in cell cycle and signal transduction events.

Pathways

ANKRD50 integrates into cellular mechanisms that include signal transduction and protein trafficking pathways. It shows interactions with other proteins within the Notch signaling pathway known for its involvement in cell differentiation. ANKRD50 might also connect with proteins like Notch intracellular domain (NICD) through these pathways to affect gene transcription regulation influencing cell fate and development.

Studies have linked ANKRD50 to neurodevelopmental disorders including autism spectrum disorder (ASD). Alterations in its expression or mutations might impair the Notch signaling pathway which can contribute to such conditions. Additionally there might be an association with cancer where anomalies in pathways where ANKRD50 plays a role could drive tumor progression. Research has started to explore its relation with oncogenic proteins like p53 which could shed light on its involvement in tumorigenesis processes.