Recombinant Human Annexin-11/ANXA11 protein is a Human Full Length protein, in the 1 to 505 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
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Publications
- Arthritis & rheumatology (Hoboken, N.J.) 72:687-6932020Disease Severity Linked to Increase in Autoantibody Diversity in IgG4-Related Disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHang Liu et. al.PubMed 31612628
Key facts
- Purity
>95% SDS-PAGE
- Expression system
Escherichia coli
- Tags
His tag N-Terminus
- Applications
SDS-PAGE, MS
- Biologically active
No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M S Y P G Y P P P P G G Y P P A A P G G G P W G G A A Y P P P P S M P P I G L D N V A T Y A G Q F N Q D Y L S G M A A N M S G T F G G A N M P N L Y P G A P G A G Y P P V P P G G F G Q P P S A Q Q P V P P Y G M Y P P P G G N P P S R M P S Y P P Y P G A P V P G Q P M P P P G Q Q P P G A Y P G Q P P V T Y P G Q P P V P L P G Q Q Q P V P S Y P G Y P G S G T V T P A V P P T Q F G S R G T I T D A P G F D P L R D A E V L R K A M K G F G T D E Q A I I D C L G S R S N K Q R Q Q I L L S F K T A Y G K D L I K D L K S E L S G N F E K T I L A L M K T P V L F D I Y E I K E A I K G V G T D E A C L I E I L A S R S N E H I R E L N R A Y K A E F K K T L E E A I R S D T S G H F Q R L L I S L S Q G N R D E S T N V D M S L A Q R D A Q E L Y A A G E N R L G T D E S K F N A V L C S R S R A H L V A V F N E Y Q R M T G R D I E K S I C R E M S G D L E E G M L A V V K C L K N T P A F F A E R L N K A M R G A G T K D R T L I R I M V S R S E T D L L D I R S E Y K R M Y G K S L Y H D I S G D T S G D Y R K I L L K I C G G N D
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.
Alternative names
Annexin A11, 56 kDa autoantigen, Annexin XI, Annexin-11, Calcyclin-associated annexin 50, CAP-50, ANXA11, ANX11
Recommended products
Recombinant Human Annexin-11/ANXA11 protein is a Human Full Length protein, in the 1 to 505 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
Alternative names
Annexin A11, 56 kDa autoantigen, Annexin XI, Annexin-11, Calcyclin-associated annexin 50, CAP-50, ANXA11, ANX11
Key facts
- Purity
>95% SDS-PAGE
- Expression system
Escherichia coli
- Tags
His tag N-Terminus
- Applications
SDS-PAGE, MS
- Biologically active
No
- Accession
- P50995-1
- Animal free
No
- Species
Human
- Concentration
- Storage buffer
pH: 5
Constituents: PBS, 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.0308% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M S Y P G Y P P P P G G Y P P A A P G G G P W G G A A Y P P P P S M P P I G L D N V A T Y A G Q F N Q D Y L S G M A A N M S G T F G G A N M P N L Y P G A P G A G Y P P V P P G G F G Q P P S A Q Q P V P P Y G M Y P P P G G N P P S R M P S Y P P Y P G A P V P G Q P M P P P G Q Q P P G A Y P G Q P P V T Y P G Q P P V P L P G Q Q Q P V P S Y P G Y P G S G T V T P A V P P T Q F G S R G T I T D A P G F D P L R D A E V L R K A M K G F G T D E Q A I I D C L G S R S N K Q R Q Q I L L S F K T A Y G K D L I K D L K S E L S G N F E K T I L A L M K T P V L F D I Y E I K E A I K G V G T D E A C L I E I L A S R S N E H I R E L N R A Y K A E F K K T L E E A I R S D T S G H F Q R L L I S L S Q G N R D E S T N V D M S L A Q R D A Q E L Y A A G E N R L G T D E S K F N A V L C S R S R A H L V A V F N E Y Q R M T G R D I E K S I C R E M S G D L E E G M L A V V K C L K N T P A F F A E R L N K A M R G A G T K D R T L I R I M V S R S E T D L L D I R S E Y K R M Y G K S L Y H D I S G D T S G D Y R K I L L K I C G G N D
- Accession
- Protein length
Full Length
- Predicted molecular weight
57 kDa
- Amino acids
1 to 505
- Nature
Recombinant
- Tags
His tag N-Terminus
Specifications
- Form
Liquid
- Additional notes
ab101050 is purified using conventional chromatography techniques.
General info
- Function
Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.
- Sequence similarities
Belongs to the annexin family.
- Subcellular localisation
Nucleus envelope, Nucleus, Nucleoplasm, Cytoskeleton, Spindle
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
This product was previously labelled as Annexin A11
Supplementary info
- Activity summary
Annexin-11 also known as ANXA11 or annexin A11 is a calcium-dependent phospholipid-binding protein with a molecular mass of approximately 56 kDa. It belongs to the annexin family and functions through interactions with membrane phospholipids in a calcium-dependent manner. Annexin A11 is expressed in various tissues including the brain liver and spleen. Molecularly annexin A11 participates in vesicle trafficking endocytosis and the regulation of cell division by interacting with the mitotic spindle apparatus.
- Biological function summary
Annexin A11 plays a significant role in cellular processes such as membrane repair cell migration and apoptosis. It does not form a stable part of a large protein complex under normal conditions but interacts dynamically with other proteins during cellular events. This protein influences intracellular calcium signaling which is important for maintaining cellular homeostasis and responding to extracellular stimuli. Annexin A11 regulates actin cytoskeletal organization impacting cell motility and structural integrity.
- Pathways
Annexin A11’s functions integrate into critical cell signaling and communication pathways such as the calcium signaling pathway and apoptosis pathway. Within these pathways annexin A11 interacts with other proteins like annexin V and annexin II modifying intracellular responses to calcium fluctuations and apoptotic signals. These pathways ensure proper cellular responses to environmental changes and stress conditions facilitating processes like cell survival and programmed cell death.
- Associated diseases and disorders
Annexin A11 associates with amyotrophic lateral sclerosis (ALS) and certain types of cancer. Mutations in the ANXA11 gene correlate with the development of familial ALS where annexin A11 dysfunction affects neuronal survival and leads to motor neuron degeneration. In certain cancers elevated levels of annexin A11 may influence tumor growth through its role in cell proliferation pathways. In both ALS and cancer proteins such as SOD1 in ALS and cyclin D1 in cancer may have connections to annexin A11’s function and regulatory networks.
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1 product image
SDS-PAGE - Recombinant Human Annexin-11/ANXA11 protein (ab101050)
3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
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