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AB101050

Recombinant Human Annexin-11/ANXA11 protein

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(2 Publications)

Recombinant Human Annexin-11/ANXA11 protein is a Human Full Length protein, in the 1 to 505 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

ANX11, ANXA11, Annexin A11, 56 kDa autoantigen, Annexin XI, Annexin-11, Calcyclin-associated annexin 50, CAP-50

1 Images
SDS-PAGE - Recombinant Human Annexin-11/ANXA11 protein (AB101050)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Annexin-11/ANXA11 protein (AB101050)

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

P50995

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 5 Constituents: PBS, 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.0308% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Annexin A11
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMSYPGYPPPPGGYPPAAPGGGPWGGAAYPPPPSMPPIGLDNVATYAGQFNQDYLSGMAANMSGTFGGANMPNLYPGAPGAGYPPVPPGGFGQPPSAQQPVPPYGMYPPPGGNPPSRMPSYPPYPGAPVPGQPMPPPGQQPPGAYPGQPPVTYPGQPPVPLPGQQQPVPSYPGYPGSGTVTPAVPPTQFGSRGTITDAPGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDIYEIKEAIKGVGTDEACLIEILASRSNEHIRELNRAYKAEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMSLAQRDAQELYAAGENRLGTDESKFNAVLCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEEGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSETDLLDIRSEYKRMYGKSLYHDISGDTSGDYRKILLKICGGND","proteinLength":"Full Length","predictedMolecularWeight":"57 kDa","actualMolecularWeight":null,"aminoAcidEnd":505,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P50995","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Annexin-11 also known as ANXA11 or annexin A11 is a calcium-dependent phospholipid-binding protein with a molecular mass of approximately 56 kDa. It belongs to the annexin family and functions through interactions with membrane phospholipids in a calcium-dependent manner. Annexin A11 is expressed in various tissues including the brain liver and spleen. Molecularly annexin A11 participates in vesicle trafficking endocytosis and the regulation of cell division by interacting with the mitotic spindle apparatus.
Biological function summary

Annexin A11 plays a significant role in cellular processes such as membrane repair cell migration and apoptosis. It does not form a stable part of a large protein complex under normal conditions but interacts dynamically with other proteins during cellular events. This protein influences intracellular calcium signaling which is important for maintaining cellular homeostasis and responding to extracellular stimuli. Annexin A11 regulates actin cytoskeletal organization impacting cell motility and structural integrity.

Pathways

Annexin A11’s functions integrate into critical cell signaling and communication pathways such as the calcium signaling pathway and apoptosis pathway. Within these pathways annexin A11 interacts with other proteins like annexin V and annexin II modifying intracellular responses to calcium fluctuations and apoptotic signals. These pathways ensure proper cellular responses to environmental changes and stress conditions facilitating processes like cell survival and programmed cell death.

Annexin A11 associates with amyotrophic lateral sclerosis (ALS) and certain types of cancer. Mutations in the ANXA11 gene correlate with the development of familial ALS where annexin A11 dysfunction affects neuronal survival and leads to motor neuron degeneration. In certain cancers elevated levels of annexin A11 may influence tumor growth through its role in cell proliferation pathways. In both ALS and cancer proteins such as SOD1 in ALS and cyclin D1 in cancer may have connections to annexin A11’s function and regulatory networks.
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Specifications

Form

Liquid

Additional notes

ab101050 is purified using conventional chromatography techniques.

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General info

Function

Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.

Sequence similarities

Belongs to the annexin family.

Subcellular localisation

Nucleus envelope

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Product protocols

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Target data

Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.
See full target information ANXA11
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 14:1251134 PubMed38332916

2024

Galectin-3 and prohibitin 1 are autoantigens in IgG4-related cholangitis without clear-cut protective effects against toxic bile acids.

Applications

Unspecified application

Species

Unspecified reactive species

Remco Kersten,David C Trampert,Lowiek M Hubers,Dagmar Tolenaars,Harmjan R Vos,Stan F J van de Graaf,Ulrich Beuers

Arthritis & rheumatology (Hoboken, N.J.) 72:687-693 PubMed31612628

2020

Disease Severity Linked to Increase in Autoantibody Diversity in IgG4-Related Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Hang Liu,Cory A Perugino,Musie Ghebremichael,Zachary S Wallace,Sydney B Montesi,John H Stone,Shiv Pillai
View all publications
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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

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