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Recombinant Human Annexin-13/ANXA13 protein is a Human Full Length protein, in the 1 to 316 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.

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Images

SDS-PAGE - Recombinant Human Annexin-13/ANXA13 protein (AB105616), expandable thumbnail

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, MS

Biologically active

No

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M G N R H A K A S S P Q G F D V D R D A K K L N K A C K G M G T N E A A I I E I L S G R T S D E R Q Q I K Q K Y K A T Y G K E L E E V L K S E L S G N F E K T A L A L L D R P S E Y A A R Q L Q K A M K G L G T D E S V L I E V L C T R T N K E I I A I K E A Y Q R L F D R S L E S D V K G D T S G N L K K I L V S L L Q A N R N E G D D V D K D L A G Q D A K D L Y D A G E G R W G T D E L A F N E V L A K R S Y K Q L R A T F Q A Y Q I L I G K D I E E A I E E E T S G D L Q K A Y L T L V R C A Q D C E D Y F A E R L Y K S M K G A G T D E E T L I R I V V T R A E V D L Q G I K A K F Q E K Y Q K S L S D M V R S D T S G D F R K L L V A L L H

Reactivity data

Application

SDS-PAGE

Reactivity

Reacts

Dilution info

-

Notes

-

Application

MS

Reactivity

Reacts

Dilution info

-

Notes

-

Target data

Function

Isoform ABinds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner (PubMed:27676605, PubMed:30610115). Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup (PubMed:27676605).Isoform BBinds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium.

Alternative names

Recommended products

Recombinant Human Annexin-13/ANXA13 protein is a Human Full Length protein, in the 1 to 316 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Applications

SDS-PAGE, MS

Accession
P27216-1
Animal free

No

Species

Human

Concentration
Loading...
Storage buffer

pH: 8
Constituents: 30% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0292% EDTA, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Sequence info

Amino acid sequence

M G S S H H H H H H S S G L V P R G S H M G N R H A K A S S P Q G F D V D R D A K K L N K A C K G M G T N E A A I I E I L S G R T S D E R Q Q I K Q K Y K A T Y G K E L E E V L K S E L S G N F E K T A L A L L D R P S E Y A A R Q L Q K A M K G L G T D E S V L I E V L C T R T N K E I I A I K E A Y Q R L F D R S L E S D V K G D T S G N L K K I L V S L L Q A N R N E G D D V D K D L A G Q D A K D L Y D A G E G R W G T D E L A F N E V L A K R S Y K Q L R A T F Q A Y Q I L I G K D I E E A I E E E T S G D L Q K A Y L T L V R C A Q D C E D Y F A E R L Y K S M K G A G T D E E T L I R I V V T R A E V D L Q G I K A K F Q E K Y Q K S L S D M V R S D T S G D F R K L L V A L L H

Accession

P27216

Protein length

Full Length

Predicted molecular weight

37.5 kDa

Amino acids

1 to 316

Nature

Recombinant

Tags

His tag N-Terminus

Specifications

Form

Liquid

Additional notes

ab105616 was purified using conventional chromatography techniques.

General info

Function

Isoform A

Sequence similarities

Belongs to the annexin family.

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Previously labelled as Annexin A13.

This product was previously labelled as ANXA13

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Annexin-13 also known as ANXA13 acts mainly as a calcium-dependent phospholipid-binding protein. ANXA13 often mediates interactions between the cell membrane and cytoskeleton. Its molecular weight is around 36 kDa. Expression levels of ANXA13 are higher in intestinal tissues compared to other tissues like the liver or kidney. Researchers also find it commonly in the epithelial cells due to its role in membrane dynamics.

Biological function summary

ANXA13 functions in cellular growth processes apoptosis and signal transduction. It likely interacts with cellular structures like membranes by binding to phospholipids in the presence of calcium ions. ANXA13 does not usually operate alone but may form complexes with other proteins. Though less studied than other annexins ANXA13 contributes to cellular homeostasis essential for efficient functioning of the intestinal cells where its expression is more noticeable.

Pathways

ANXA13 plays a role in calcium signaling and membrane trafficking. It interacts with intracellular phospholipids and aids in the regulation of membrane-associated activity which is significant in endocytosis pathways. ANXA13 potentially shares functional relationships with other annexins like ANXA1 and ANXA5 within these pathways aligning them in coordinating cellular responses to calcium ion changes.

Associated diseases and disorders

ANXA13 seems associated with specific gastrointestinal diseases and possibly certain cancers. Altered expression of ANXA13 occurs in intestinal inflammation and could impact diseases like Inflammatory Bowel Disease (IBD). Moreover changes in ANXA13 expression or function have implications in colorectal cancer development often in conjunction with other annexins such as ANXA4. Understanding ANXA13's involvement could help in developing therapeutic approaches to manage these conditions efficiently.

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1 product image

  • SDS-PAGE - Recombinant Human Annexin-13/ANXA13 protein (ab105616), expandable thumbnail

    SDS-PAGE - Recombinant Human Annexin-13/ANXA13 protein (ab105616)

    15% SDS-PAGE analysis of 3μg ab105616.

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Product protocols

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