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AB105616

Recombinant Human Annexin-13/ANXA13 protein

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Recombinant Human Annexin-13/ANXA13 protein is a Human Full Length protein, in the 1 to 316 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

ANX13, ANXA13, Annexin A13, Annexin XIII, Annexin-13, Intestine-specific annexin, ISA

1 Images
SDS-PAGE - Recombinant Human Annexin-13/ANXA13 protein (AB105616)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Annexin-13/ANXA13 protein (AB105616)

15% SDS-PAGE analysis of 3μg ab105616.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

P27216

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0292% EDTA, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Previously labelled as Annexin A13.

This product was previously labelled as ANXA13

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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGNRHAKASSPQGFDVDRDAKKLNKACKGMGTNEAAIIEILSGRTSDERQQIKQKYKATYGKELEEVLKSELSGNFEKTALALLDRPSEYAARQLQKAMKGLGTDESVLIEVLCTRTNKEIIAIKEAYQRLFDRSLESDVKGDTSGNLKKILVSLLQANRNEGDDVDKDLAGQDAKDLYDAGEGRWGTDELAFNEVLAKRSYKQLRATFQAYQILIGKDIEEAIEEETSGDLQKAYLTLVRCAQDCEDYFAERLYKSMKGAGTDEETLIRIVVTRAEVDLQGIKAKFQEKYQKSLSDMVRSDTSGDFRKLLVALLH","proteinLength":"Full Length","predictedMolecularWeight":"37.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":316,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P27216","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Annexin-13 also known as ANXA13 acts mainly as a calcium-dependent phospholipid-binding protein. ANXA13 often mediates interactions between the cell membrane and cytoskeleton. Its molecular weight is around 36 kDa. Expression levels of ANXA13 are higher in intestinal tissues compared to other tissues like the liver or kidney. Researchers also find it commonly in the epithelial cells due to its role in membrane dynamics.
Biological function summary

ANXA13 functions in cellular growth processes apoptosis and signal transduction. It likely interacts with cellular structures like membranes by binding to phospholipids in the presence of calcium ions. ANXA13 does not usually operate alone but may form complexes with other proteins. Though less studied than other annexins ANXA13 contributes to cellular homeostasis essential for efficient functioning of the intestinal cells where its expression is more noticeable.

Pathways

ANXA13 plays a role in calcium signaling and membrane trafficking. It interacts with intracellular phospholipids and aids in the regulation of membrane-associated activity which is significant in endocytosis pathways. ANXA13 potentially shares functional relationships with other annexins like ANXA1 and ANXA5 within these pathways aligning them in coordinating cellular responses to calcium ion changes.

ANXA13 seems associated with specific gastrointestinal diseases and possibly certain cancers. Altered expression of ANXA13 occurs in intestinal inflammation and could impact diseases like Inflammatory Bowel Disease (IBD). Moreover changes in ANXA13 expression or function have implications in colorectal cancer development often in conjunction with other annexins such as ANXA4. Understanding ANXA13's involvement could help in developing therapeutic approaches to manage these conditions efficiently.
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Specifications

Form

Liquid

Additional notes

ab105616 was purified using conventional chromatography techniques.

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General info

Function

Isoform A. Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner (PubMed : 27676605, PubMed : 30610115). Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup (PubMed : 27676605).. Isoform B. Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium.

Sequence similarities

Belongs to the annexin family.

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Product protocols

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Target data

Isoform A. Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner (PubMed : 27676605, PubMed : 30610115). Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup (PubMed : 27676605).. Isoform B. Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium.
See full target information ANXA13
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Complementary Products

Primary Antibodies

AB151517

Anti-Annexin-13/ANXA13 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Annexin-13/ANXA13 antibody (AB151517)

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  • 0
Assay Kits

AB283992

Human Annexin-A13/ANXA13 ELISA Kit

Sandwich ELISA - Human Annexin-A13/ANXA13 ELISA Kit (AB283992)

  • 0
  • 0

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