Recombinant Human Annexin-13/ANXA13 protein is a Human Full Length protein, in the 1 to 316 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
>90% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE, MS
No
M G S S H H H H H H S S G L V P R G S H M G N R H A K A S S P Q G F D V D R D A K K L N K A C K G M G T N E A A I I E I L S G R T S D E R Q Q I K Q K Y K A T Y G K E L E E V L K S E L S G N F E K T A L A L L D R P S E Y A A R Q L Q K A M K G L G T D E S V L I E V L C T R T N K E I I A I K E A Y Q R L F D R S L E S D V K G D T S G N L K K I L V S L L Q A N R N E G D D V D K D L A G Q D A K D L Y D A G E G R W G T D E L A F N E V L A K R S Y K Q L R A T F Q A Y Q I L I G K D I E E A I E E E T S G D L Q K A Y L T L V R C A Q D C E D Y F A E R L Y K S M K G A G T D E E T L I R I V V T R A E V D L Q G I K A K F Q E K Y Q K S L S D M V R S D T S G D F R K L L V A L L H
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Isoform ABinds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner (PubMed:27676605, PubMed:30610115). Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup (PubMed:27676605).Isoform BBinds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium.
ANX13, ANXA13, Annexin A13, Annexin XIII, Annexin-13, Intestine-specific annexin, ISA
Recombinant Human Annexin-13/ANXA13 protein is a Human Full Length protein, in the 1 to 316 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
>90% SDS-PAGE
Escherichia coli
His tag N-Terminus
SDS-PAGE, MS
No
No
Human
pH: 8
Constituents: 30% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0292% EDTA, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
M G S S H H H H H H S S G L V P R G S H M G N R H A K A S S P Q G F D V D R D A K K L N K A C K G M G T N E A A I I E I L S G R T S D E R Q Q I K Q K Y K A T Y G K E L E E V L K S E L S G N F E K T A L A L L D R P S E Y A A R Q L Q K A M K G L G T D E S V L I E V L C T R T N K E I I A I K E A Y Q R L F D R S L E S D V K G D T S G N L K K I L V S L L Q A N R N E G D D V D K D L A G Q D A K D L Y D A G E G R W G T D E L A F N E V L A K R S Y K Q L R A T F Q A Y Q I L I G K D I E E A I E E E T S G D L Q K A Y L T L V R C A Q D C E D Y F A E R L Y K S M K G A G T D E E T L I R I V V T R A E V D L Q G I K A K F Q E K Y Q K S L S D M V R S D T S G D F R K L L V A L L H
Full Length
37.5 kDa
1 to 316
Recombinant
His tag N-Terminus
Liquid
ab105616 was purified using conventional chromatography techniques.
Isoform A
Belongs to the annexin family.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Previously labelled as Annexin A13.
This product was previously labelled as ANXA13
This supplementary information is collated from multiple sources and compiled automatically.
Annexin-13 also known as ANXA13 acts mainly as a calcium-dependent phospholipid-binding protein. ANXA13 often mediates interactions between the cell membrane and cytoskeleton. Its molecular weight is around 36 kDa. Expression levels of ANXA13 are higher in intestinal tissues compared to other tissues like the liver or kidney. Researchers also find it commonly in the epithelial cells due to its role in membrane dynamics.
ANXA13 functions in cellular growth processes apoptosis and signal transduction. It likely interacts with cellular structures like membranes by binding to phospholipids in the presence of calcium ions. ANXA13 does not usually operate alone but may form complexes with other proteins. Though less studied than other annexins ANXA13 contributes to cellular homeostasis essential for efficient functioning of the intestinal cells where its expression is more noticeable.
ANXA13 plays a role in calcium signaling and membrane trafficking. It interacts with intracellular phospholipids and aids in the regulation of membrane-associated activity which is significant in endocytosis pathways. ANXA13 potentially shares functional relationships with other annexins like ANXA1 and ANXA5 within these pathways aligning them in coordinating cellular responses to calcium ion changes.
ANXA13 seems associated with specific gastrointestinal diseases and possibly certain cancers. Altered expression of ANXA13 occurs in intestinal inflammation and could impact diseases like Inflammatory Bowel Disease (IBD). Moreover changes in ANXA13 expression or function have implications in colorectal cancer development often in conjunction with other annexins such as ANXA4. Understanding ANXA13's involvement could help in developing therapeutic approaches to manage these conditions efficiently.
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15% SDS-PAGE analysis of 3μg ab105616.
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