Recombinant Human Annexin-6/ANXA6 protein is a Human Full Length protein, in the 1 to 673 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
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- eLife 9:2020ER-luminal [Ca] regulation of InsP receptor gating mediated by an ER-luminal peripheral Ca-binding protein.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHoria Vais et. al.PubMed 32420875
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M A K P A Q G A K Y R G S I H D F P G F D P N Q D A E A L Y T A M K G F G S D K E A I L D I I T S R S N R Q R Q E V C Q S Y K S L Y G K D L I A D L K Y E L T G K F E R L I V G L M R P P A Y C D A K E I K D A I S G I G T D E K C L I E I L A S R T N E Q M H Q L V A A Y K D A Y E R D L E A D I I G D T S G H F Q K M L V V L L Q G T R E E D D V V S E D L V Q Q D V Q D L Y E A G E L K W G T D E A Q F I Y I L G N R S K Q H L R L V F D E Y L K T T G K P I E A S I R G E L S G D F E K L M L A V V K C I R S T P E Y F A E R L F K A M K G L G T R D N T L I R I M V S R S E L D M L D I R E I F R T K Y E K S L Y S M I K N D T S G E Y K K T L L K L S G G D D D A A G Q F F P E A A Q V A Y Q M W E L S A V A R V E L K G T V R P A N D F N P D A D A K A L R K A M K G L G T D E D T I I D I I T H R S N V Q R Q Q I R Q T F K S H F G R D L M T D L K S E I S G D L A R L I L G L M M P P A H Y D A K Q L K K A M E G A G T D E K A L I E I L A T R T N A E I R A I N E A Y K E D Y H K S L E D A L S S D T S G H F R R I L I S L A T G H R E E G G E N L D Q A R E D A Q V A A E I L E I A D T P S G D K T S L E T R F M T I L C T R S Y P H L R R V F Q E F I K M T N Y D V E H T I K K E M S G D V R D A F V A I V Q S V K N K P L F F A D K L Y K S M K G A G T D E K T L T R I M V S R S E I D L L N I R R E F I E K Y D K S L H Q A I E G D T S G D F L K A L L A L C G G E D
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Associated Products
Select an associated product type
1 product for Alternative Product
Target data
Function
May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
Alternative names
ANX6, ANXA6, Annexin A6, 67 kDa calelectrin, Annexin VI, Annexin-6, Calphobindin-II, Chromobindin-20, Lipocortin VI, Protein III, p68, p70, CPB-II
Recommended products
Recombinant Human Annexin-6/ANXA6 protein is a Human Full Length protein, in the 1 to 673 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- Tag free
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P08133-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M A K P A Q G A K Y R G S I H D F P G F D P N Q D A E A L Y T A M K G F G S D K E A I L D I I T S R S N R Q R Q E V C Q S Y K S L Y G K D L I A D L K Y E L T G K F E R L I V G L M R P P A Y C D A K E I K D A I S G I G T D E K C L I E I L A S R T N E Q M H Q L V A A Y K D A Y E R D L E A D I I G D T S G H F Q K M L V V L L Q G T R E E D D V V S E D L V Q Q D V Q D L Y E A G E L K W G T D E A Q F I Y I L G N R S K Q H L R L V F D E Y L K T T G K P I E A S I R G E L S G D F E K L M L A V V K C I R S T P E Y F A E R L F K A M K G L G T R D N T L I R I M V S R S E L D M L D I R E I F R T K Y E K S L Y S M I K N D T S G E Y K K T L L K L S G G D D D A A G Q F F P E A A Q V A Y Q M W E L S A V A R V E L K G T V R P A N D F N P D A D A K A L R K A M K G L G T D E D T I I D I I T H R S N V Q R Q Q I R Q T F K S H F G R D L M T D L K S E I S G D L A R L I L G L M M P P A H Y D A K Q L K K A M E G A G T D E K A L I E I L A T R T N A E I R A I N E A Y K E D Y H K S L E D A L S S D T S G H F R R I L I S L A T G H R E E G G E N L D Q A R E D A Q V A A E I L E I A D T P S G D K T S L E T R F M T I L C T R S Y P H L R R V F Q E F I K M T N Y D V E H T I K K E M S G D V R D A F V A I V Q S V K N K P L F F A D K L Y K S M K G A G T D E K T L T R I M V S R S E I D L L N I R R E F I E K Y D K S L H Q A I E G D T S G D F L K A L L A L C G G E D
- Accession
- P08133
- Protein length
- Full Length
- Amino acids
- 1 to 673
- Nature
- Recombinant
Specifications
- Form
- Liquid
- Additional notes
ab92934 is purified using conventional chromatography techniques.
General info
- Function
May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
- Sequence similarities
Belongs to the annexin family.
- Post-translational modifications
Phosphorylated in response to growth factor stimulation.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product was previously labelled as Annexin VI
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Annexin-6 also known as ANXA6 is a member of the annexin family of proteins. It has a mass of approximately 68 kDa and is expressed in various tissues with substantial presence in muscle and liver. This protein acts mechanically by binding to membranes in a calcium-dependent manner playing a role in membrane-associated processes such as endocytosis and exocytosis. Annexin-6 can also interact with cytoskeletal elements influencing cell structure and stability.
- Biological function summary
Annexin-6 functions as a versatile scaffold that organizes multiprotein complexes. It modulates membrane trafficking processes and participates in signaling pathways within the cell. This protein can influence intracellular calcium homeostasis by interacting with calcium channels and transporters making it an integral part of cellular signaling and communication.
- Pathways
Annexin-6 plays a role in the MAPK and PI3K/Akt signaling pathways. It associates with proteins such as Ras and Protein Kinase C impacting cell proliferation survival and differentiation. These interactions highlight the importance of annexin-6 in cellular responses to external stimuli and help regulate various physiological processes in the body.
- Associated diseases and disorders
Annexin-6 has been linked to cardiac disorders and cancer. In the context of cardiac health it interacts with proteins like phospholamban and calmodulin to influence heart muscle function and calcium regulation. In cancer annexin-6's involvement in the Akt signaling pathway can affect tumor growth and metastasis often interacting with other proteins like EGFR and HER2. This makes it a significant protein of interest in disease research and potential therapeutic targeting.
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1 product image
SDS-PAGE - Recombinant Human Annexin-6/ANXA6 protein (ab92934)
15% SDS-PAGE showing ab92934 (Annexin-6/ANXA6 protein) at approximately 78 kDa (3 μg).
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