Recombinant Human ANR44 protein (His-DHFR tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ANR44 also known as Antisense RNA 44 plays a role in gene regulation through its action in RNA silencing mechanisms. It has a molecular mass of approximately 70 kDa. Researchers have observed its expression in a variety of tissues including heart liver and kidney. The RNA molecule interacts directly with RNA-binding proteins to exert its control over the transcriptional and post-transcriptional modification processes.

Biological function summary

ANR44 influences cellular processes by forming part of a ribonucleoprotein complex. This complex assists in regulating mRNA stability and translation repression affecting the gene expression involved in cell cycle control and apoptosis. Additionally ANR44 is known to work with other RNA molecules modulating their functions and enhancing the precision of their actions.

Pathways

ANR44 participates primarily in the RNA interference pathway where it influences gene silencing. It shows interaction with proteins such as Dicer and Argonaute essential components of this pathway. Moreover ANR44 is involved in the regulation of the mTOR pathway which contributes to cell growth and proliferation control.

ANR44 has associations with cancer and cardiovascular diseases. In cancer when its expression patterns become disrupted it may lead to uncontrolled cell growth due to its involvement with mTOR signaling often alongside proteins like PTEN. In cardiovascular disorders its dysregulation can contribute to improper cellular responses in heart tissues influencing disease progression by interacting with proteins like AMPK that manage cellular energy balance.