JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB157866

Recombinant Human AP1B1 protein (GST tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human AP1B1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 939 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

ADTB1, BAM22, CLAPB2, AP1B1, AP-1 complex subunit beta-1, Adaptor protein complex AP-1 subunit beta-1, Adaptor-related protein complex 1 subunit beta-1, Beta-1-adaptin, Beta-adaptin 1, Clathrin assembly protein complex 1 beta large chain, Golgi adaptor HA1/AP1 adaptin beta subunit

1 Images
SDS-PAGE - Recombinant Human AP1B1 protein (GST tag N-Terminus) (AB157866)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human AP1B1 protein (GST tag N-Terminus) (AB157866)

ab157866 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q10567

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Complementary Products

Primary Antibodies

AB230273

Anti-AP1M1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AP1M1 antibody (AB230273)

  • 0
  • 0
Cell Lines & Lysates

AB266200

Human AP1B1 knockout HEK-293T cell line

Sanger Sequencing - Human AP1B1 knockout HEK-293T cell line (AB266200)

  • 0
  • 0
Cell Lines & Lysates

AB263089

Human AP1B1 knockout HEK-293T cell lysate

Sanger Sequencing - Human AP1B1 knockout HEK-293T cell lysate (AB263089)

  • 0
  • 0
Assay Kits

AB207196

AP1 (c-Fos/FosB/Fra1/c-Jun/JunD) Transcription Factor Assay Kit (Colorimetric)

Functional Studies - AP1 (c-Fos/FosB/Fra1/c-Jun/JunD) Transcription Factor Assay Kit (Colorimetric) (AB207196)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASSESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLGGGLDSLIGGTNFVAPPTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQSLKLTNGIWVLAELRIQPGNPSCTLSLKCRAPEVSQHVYQAYETILKN","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":939,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q10567","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

AP1B1 also known as Adaptor-related protein complex 1 subunit beta-1 is involved in mechanical functions related to protein sorting and vesicle formation. It has a molecular mass of approximately 105 kDa. This protein forms part of the AP-1 complex which is present in various cell types particularly expressed in epithelial tissues. AP1B1 functions as an important component in clathrin-coated vesicle transport assisting in the selection of cargo that is transported between the trans-Golgi network and endosomes.
Biological function summary

The role of the AP1B1 extends to ensuring proper cellular trafficking maintaining cell polarity and function within epithelial cells. As part of the AP-1 complex it interacts with other subunits to facilitate the budding of vesicles a critical step in cell function and homeostasis. AP1B1's involvement in intracellular transport underlines its significance in cellular processes that require precise protein localization and distribution.

Pathways

The AP1B1 protein plays an essential role in the clathrin-mediated endocytosis and post-Golgi trafficking pathways. It operates alongside other proteins like clathrin and AP-1 γ subunit coordinating the transport of receptors and other protein complexes to their specific intracellular destinations. This molecular coordination supports processes such as receptor recycling and lysosomal targeting within the cell environment.

Errors in AP1B1 function can link to specific medical conditions such as Hermansky-Pudlak syndrome and neurodegenerative diseases. In these conditions alterations in the AP1B1 protein may disrupt normal vesicle trafficking and protein sorting processes. The disorder-related disruption illustrates how AP1B1 potentially interacting with proteins like the lysosomal-associated membrane protein 2 can impact cellular homeostasis and lead to systemic effects in tissue biology.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes (PubMed : 31630791). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Sequence similarities

Belongs to the adaptor complexes large subunit family.

style
left-column

Product protocols

style
left-column

Target data

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes (PubMed : 31630791). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
See full target information AP1B1
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com