Recombinant Human AP4E1 protein is a Human Fragment protein, in the 951 to 1136 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
>95%
Escherichia coli
Tag free
SDS-PAGE
No
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).
AP-4 complex subunit epsilon-1, AP-4 adaptor complex subunit epsilon, Adaptor-related protein complex 4 subunit epsilon-1, Epsilon subunit of AP-4, Epsilon-adaptin, AP4E1
Recombinant Human AP4E1 protein is a Human Fragment protein, in the 951 to 1136 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE.
AP-4 complex subunit epsilon-1, AP-4 adaptor complex subunit epsilon, Adaptor-related protein complex 4 subunit epsilon-1, Epsilon subunit of AP-4, Epsilon-adaptin, AP4E1
>95%
Escherichia coli
Tag free
SDS-PAGE
No
No
Human
Reconstitute with water to desired concentration.
Constituents: 0.58% Sodium chloride
Fragment
951 to 1136
Recombinant
Lyophilized
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).
Belongs to the adaptor complexes large subunit family.
Blue Ice
-20°C
Avoid freeze / thaw cycle, Reconstitute for long term storage
This supplementary information is collated from multiple sources and compiled automatically.
AP4E1 also known as Adaptor Related Protein Complex 4 Epsilon 1 Subunit functions as a component of the adaptor protein complex 4 (AP-4). It has a mass of approximately 110 kDa. AP4E1 plays a role in the recruitment of clathrin-coated vesicles and is found mainly in the trans-Golgi network. The protein is expressed in several tissues with notable presence in the central nervous system and various epithelial cells.
AP4E1 facilitates the sorting of cargo proteins at the trans-Golgi network contributing to intracellular trafficking. It forms part of the AP-4 complex that includes other subunits like AP4S1 AP4B1 and AP4M1. This complex binds to sorting signals on the cytoplasmic tails of membrane proteins directing them to their appropriate intracellular destinations.
AP4E1 participates in protein sorting mechanisms that influence the traffic of lysosomal enzymes and other cargo proteins. It interacts with SNX27 a protein that links endosomal sorting to signal transduction pathways. AP4E1 has relations with pathways involving endocytosis and membrane trafficking particularly those that regulate cellular homeostasis and signaling.
Altered function or expression of AP4E1 associates with neurological disorders such as hereditary spastic paraplegia. Mutations in this protein can lead to disruptions in neural pathways similar to the effects seen with related proteins like AP4B1. Studies suggest connections to other genetic conditions involving cognitive impairment highlighting the protein's importance in proper neuronal function.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com