Recombinant Human Apelin protein is a Human Full Length protein, in the 1 to 77 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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- Oxidative medicine and cellular longevity 2023:50124742023The Interaction of Apelin and FGFR1 Ameliorated the Kidney Fibrosis through Suppression of TGF-Induced Endothelial-to-Mesenchymal Transition.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRongfen Gao,Yumin Wu,Qian Yang,Liangdong Chen,Jiwei Chen,Boyong Wang,Zeming Liu,Juan Jin,Jinpeng Li,Gaosong WuPubMed 36785790
- Frontiers in cardiovascular medicine 9:9560412022Empagliflozin prevents neointima formation by impairing smooth muscle cell proliferation and accelerating endothelial regeneration.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJochen Dutzmann,Lena Marie Bode,Katrin Kalies,Laura Korte,Kai Knöpp,Frederik Julius Kloss,Mirja Sirisko,Claudia Pilowski,Susanne Koch,Heiko Schenk,Jan-Marcus Daniel,Johann Bauersachs,Daniel G SeddingPubMed 36017090
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M N L R L C V Q A L L L L W L S L T A V C G G S L M P L P D G N G L E D G N V R H L V Q P R G S R N G P G P W Q G G R R K F R R Q R P R L S H K G P M P F
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Endogenous ligand for the apelin receptor (APLNR) (PubMed:10525157). Drives internalization of the apelin receptor (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity). Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (By similarity). (Microbial infection) Endogenous ligand for the apelin receptor (APLNR), an alternative coreceptor with CD4 for HIV-1 infection (PubMed:11090199). Inhibits HIV-1 entry in cells coexpressing CD4 and APLNR (PubMed:11090199). Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives (PubMed:11090199).
Alternative names
APEL, APLN, Apelin, APJ endogenous ligand
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Recombinant Human Apelin protein is a Human Full Length protein, in the 1 to 77 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q9ULZ1-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M N L R L C V Q A L L L L W L S L T A V C G G S L M P L P D G N G L E D G N V R H L V Q P R G S R N G P G P W Q G G R R K F R R Q R P R L S H K G P M P F
- Accession
- Q9ULZ1
- Protein length
- Full Length
- Amino acids
- 1 to 77
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Endogenous ligand for the apelin receptor (APLNR) (PubMed:10525157). Drives internalization of the apelin receptor (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity). Plays a role in early coronary blood vessels formation (By similarity). Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior (By similarity).
- Sequence similarities
Belongs to the apelin family.
- Post-translational modifications
Several active peptides may be produced by proteolytic processing of the peptide precursor.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Apelin also known as APLN is a peptide ligand with a mass of approximately 77 amino acids. It has gained attention in scientific research due to its interaction with the G-protein coupled receptor named APJ (Apelin receptor). Apelin expresses widely in various tissues including heart lung kidney and gastrointestinal tract. This widespread expression suggests it plays roles in multiple physiological processes.
- Biological function summary
Apelin acts as an important regulator of cardiovascular functions and fluid homeostasis. It modulates blood pressure and cardiac contractility indicating its role in maintaining cardiovascular health. Apelin operates independently but interacts closely with its receptor APJ forming a functional complex that initiates various intracellular signaling mechanisms. Researchers have noted its significant effects on the vascular system and potential involvement in angiogenesis.
- Pathways
Apelin participates in the renin-angiotensin system and influences the nitric oxide signaling pathway. These pathways are important for maintaining vascular tone and pressure as well as for ensuring proper fluid balance in the body. Apelin's actions appear related to the angiotensin II type 1 receptor and endothelial nitric oxide synthase affecting their activity to achieve desired physiological outcomes. This involvement illustrates how apelin bridges different signaling networks to regulate homeostasis.
- Associated diseases and disorders
Apelin has connections to cardiovascular disorders and metabolic syndrome. High apelin levels have been observed in heart failure indicating its compensatory role in maintaining cardiovascular function. Additionally disruptions in apelin signaling may link to obesity-related diabetes given its effects on insulin sensitivity and energy metabolism. The interplay between apelin APJ and angiotensin II type 1 receptor highlights its potential as a therapeutic target for managing these conditions.
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1 product image
SDS-PAGE - Recombinant Human Apelin protein (ab152927)
ab152927 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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