Recombinant Human APLP1 protein (His tag) is a Human Fragment protein, in the 1 to 580 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G P A S P A A R G L S R R P G Q P P L P L L L P L L L L L L R A Q P A I G S L A G G S P G A A E A P G S A Q V A G L C G R L T L H R D L R T G R W E P D P Q R S R R C L R D P Q R V L E Y C R Q M Y P E L Q I A R V E Q A T Q A I P M E R W C G G S R S G S C A H P H H Q V V P F R C L P G E F V S E A L L V P E G C R F L H Q E R M D Q C E S S T R R H Q E A Q E A C S S Q G L I L H G S G M L L P C G S D R F R G V E Y V C C P P P G T P D P S G T A V G D P S T R S W P P G S R V E G A E D E E E E E S F P Q P V D D Y F V E P P Q A E E E E E T V P P P S S H T L A V V G K V T P T P R P T D G V D I Y F G M P G E I S E H E G F L R A K M D L E E R R M R Q I N E V M R E W A M A D N Q S K N L P K A D R Q A L N E H F Q S I L Q T L E E Q V S G E R Q R L V E T H A T R V I A L I N D Q R R A A L E G F L A A L Q A D P P Q A E R V L L A L R R Y L R A E Q K E Q R H T L R H Y Q H V A A V D P E K A Q Q M R F Q V H T H L Q V I E E R V N Q S L G L L D Q N P H L A Q E L R P Q I Q E L L H S E H L G P S E L E A P A P G G S S E D K G G L Q P P D S K D D T P M T L P K G S T E Q D A A S P E K E K M N P L E Q Y E R K V N A S V P R G F P F H S S E I Q R D E L A P A G T G V S R E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
Alternative names
Amyloid beta precursor like protein 1, Amyloid beta (A4) precursor-like protein 1, Amyloid-like protein 1, APLP, APLP-1, APLP1
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Recombinant Human APLP1 protein (His tag) is a Human Fragment protein, in the 1 to 580 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >95% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P51693-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M G P A S P A A R G L S R R P G Q P P L P L L L P L L L L L L R A Q P A I G S L A G G S P G A A E A P G S A Q V A G L C G R L T L H R D L R T G R W E P D P Q R S R R C L R D P Q R V L E Y C R Q M Y P E L Q I A R V E Q A T Q A I P M E R W C G G S R S G S C A H P H H Q V V P F R C L P G E F V S E A L L V P E G C R F L H Q E R M D Q C E S S T R R H Q E A Q E A C S S Q G L I L H G S G M L L P C G S D R F R G V E Y V C C P P P G T P D P S G T A V G D P S T R S W P P G S R V E G A E D E E E E E S F P Q P V D D Y F V E P P Q A E E E E E T V P P P S S H T L A V V G K V T P T P R P T D G V D I Y F G M P G E I S E H E G F L R A K M D L E E R R M R Q I N E V M R E W A M A D N Q S K N L P K A D R Q A L N E H F Q S I L Q T L E E Q V S G E R Q R L V E T H A T R V I A L I N D Q R R A A L E G F L A A L Q A D P P Q A E R V L L A L R R Y L R A E Q K E Q R H T L R H Y Q H V A A V D P E K A Q Q M R F Q V H T H L Q V I E E R V N Q S L G L L D Q N P H L A Q E L R P Q I Q E L L H S E H L G P S E L E A P A P G G S S E D K G G L Q P P D S K D D T P M T L P K G S T E Q D A A S P E K E K M N P L E Q Y E R K V N A S V P R G F P F H S S E I Q R D E L A P A G T G V S R E
- Accession
- P51693
- Protein length
- Fragment
- Predicted molecular weight
- 61.9 kDa
- Amino acids
- 1 to 580
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
- Sequence similarities
Belongs to the APP family.
- Post-translational modifications
Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3 (By similarity).
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
APLP1 also known as amyloid precursor-like protein 1 is a protein with a molecular mass of approximately 91 kDa. Researchers have observed its expression in the brain particularly in regions like the cortex and hippocampus. This protein shares structural similarities with the Amyloid Precursor Protein (APP) family and plays important roles in cellular functions through its protein domains and motifs.
- Biological function summary
APLP1 functions by contributing to cell-cell adhesion and synaptic formation impacting neuronal development. It forms part of a larger protein complex that modulates these processes interacting with other proteins to maintain cellular communication. This protein's activity supports the stability and plasticity of synapses which is essential for proper neural network function.
- Pathways
Proteins related to APLP1 participate notably in the Notch signaling and MAPK pathways. These pathways influence cell fate decisions growth and survival. APLP1 interacts with proteins such as APP and APLP2 both of which also engage in similar signaling pathways. This interconnectedness highlights APLP1's role in neurobiological processes essential for normal brain operation.
- Associated diseases and disorders
Researchers link APLP1 to neurodegenerative disorders like Alzheimer's disease and autism spectrum disorders. Changes in APLP1 expression or function can affect amyloidogenic processing connecting it to APP and potentially leading to plaque formation a hallmark of Alzheimer's disease. Additionally this protein's relationship with synaptic function may contribute to the pathophysiology observed in autism spectrum disorders where alterations in synaptic communication are common.
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SDS-PAGE - Recombinant Human APLP1 protein (His tag) (ab276580)
SDS-PAGE analysis of ab276580
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