Recombinant Human APOA1BP protein (His tag)
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Recombinant Human APOA1BP protein (His tag) is a Human Full Length protein, in the 1 to 288 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
AIBP, APOA1BP, YJEFN1, NAXE, NAD(P)H-hydrate epimerase, Apolipoprotein A-I-binding protein, NAD(P)HX epimerase, YjeF N-terminal domain-containing protein 1, AI-BP, YjeF_N1
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human APOA1BP protein (His tag) (AB276539)
SDS-PAGE analysis of ab276539
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
APOA1BP aids in stabilizing cellular processes that regulate lipid transport and cholesterol efflux. It works in close association with apolipoprotein A1 forming a functional complex that helps maintain lipid balance within cells. This interaction supports numerous cellular functions that are significant for normal metabolic activity.
Pathways
APOA1BP integrates into the reverse cholesterol transport pathway which is vital for recycling cholesterol from peripheral tissues back to the liver for excretion. It influences interactions with significant proteins such as HDL and other apolipoproteins contributing to cholesterol metabolism. Another related pathway involves lipid absorption where APOA1BP functions to facilitate efficient lipid distribution.
Specifications
Form
Lyophilized
General info
Function
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) (PubMed : 27616477). This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity). Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (PubMed : 23719382).
Sequence similarities
Belongs to the NnrE/AIBP family.
Post-translational modifications
Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.
Subcellular localisation
Mitochondrion
Target data
Complementary Products
Product promise
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