Recombinant Human APOBEC4 protein is a Human Full Length protein, in the 1 to 367 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
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| Application | Reactivity | Dilution info | Notes |
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Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Putative C to U editing enzyme whose physiological substrate is not yet known.
C1orf169, APOBEC4, Putative C->U-editing enzyme APOBEC-4, Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4
Recombinant Human APOBEC4 protein is a Human Full Length protein, in the 1 to 367 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
pH: 8
Constituents: 0.32% Tris HCl
Putative C to U editing enzyme whose physiological substrate is not yet known.
Belongs to the cytidine and deoxycytidylate deaminase family.
APOBEC4 is a member of the APOBEC family of proteins which are cytidine deaminases known for their role in editing RNA and DNA sequences. This protein with a mass of approximately 43 kDa shows expression in various human tissues but is particularly noted in testis. It operates by converting cytidine to uridine in single-stranded DNA which suggests it might participate in genetic regulation processes along with other APOBEC proteins.
APOBEC4 participates in mutational processes that potentially contribute to genomic diversity. Although detailed functions remain less understood compared to its family members there is evidence to suggest its involvement in germ cell mutation processes. It doesn't expressly form any identified complex like other well-characterized APOBEC members but its potential role might involve interactions that influence genetic sequence variation.
APOBEC4's actions can imply a role in pathways involving nucleic acid metabolism. It aligns with pathways linked to RNA modification and potentially impacts the integrity of genetic information during transcription. Other proteins like APOBEC3A and APOBEC3B also participate in similar mutational and editing processes reflecting a possible overlap in pathway involvement that suggests a regulatory network maintaining genetic fidelity.
APOBEC4 remains not fully implicated yet its family members have known roles in cancer pointing to a potential link. Its functions tie to disorders associated with genomic instability possibly connecting with mutagenic activities leading to oncogenesis. Examination of APOBEC4 within cancer pathways involves looking at how APOBEC3 proteins also contribute to tumorigenesis hinting at a shared mechanistic influence across this protein family.
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