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AB171472

Recombinant Human APOBEC4 protein (denatured)

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Recombinant Human APOBEC4 protein (denatured) is a Human Full Length protein, in the 1 to 367 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

C1orf169, APOBEC4, Putative C->U-editing enzyme APOBEC-4, Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4

1 Images
SDS-PAGE - Recombinant Human APOBEC4 protein (denatured) (AB171472)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human APOBEC4 protein (denatured) (AB171472)

15% SDS-PAGE analysis of 3µg ab171472.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q8WW27

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMEPIYEEYLANHGTIVKPYYWLSFSLDCSNCPYHIRTGEEARVSLTEFCQIFGFPYGTTFPQTKHLTFYELKTSSGSLVQKGHASSCTGNYIHPESMLFEMNGYLDSAIYNNDSIRHIILYSNNSPCNEANHCCISKMYNFLITYPGITLSIYFSQLYHTEMDFPASAWNREALRSLASLWPRVVLSPISGGIWHSVLHSFISGVSGSHVFQPILTGRALADRHNAYEINAITGVKPYFTDVLLQTKRNPNTKAQEALESYPLNNAFPGQFFQMPSGQLQPNLPPDLRAPVVFVLVPLRDLPPMHMGQNPNKPRNIVRHLNMPQMSFQETKDLGRLPTGRSVEIVEITEQFASSKEADEKKKKKGKK","proteinLength":"Full Length","predictedMolecularWeight":"44 kDa","actualMolecularWeight":null,"aminoAcidEnd":367,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8WW27","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

APOBEC4 is a member of the APOBEC family of proteins which are cytidine deaminases known for their role in editing RNA and DNA sequences. This protein with a mass of approximately 43 kDa shows expression in various human tissues but is particularly noted in testis. It operates by converting cytidine to uridine in single-stranded DNA which suggests it might participate in genetic regulation processes along with other APOBEC proteins.
Biological function summary

APOBEC4 participates in mutational processes that potentially contribute to genomic diversity. Although detailed functions remain less understood compared to its family members there is evidence to suggest its involvement in germ cell mutation processes. It doesn't expressly form any identified complex like other well-characterized APOBEC members but its potential role might involve interactions that influence genetic sequence variation.

Pathways

APOBEC4's actions can imply a role in pathways involving nucleic acid metabolism. It aligns with pathways linked to RNA modification and potentially impacts the integrity of genetic information during transcription. Other proteins like APOBEC3A and APOBEC3B also participate in similar mutational and editing processes reflecting a possible overlap in pathway involvement that suggests a regulatory network maintaining genetic fidelity.

APOBEC4 remains not fully implicated yet its family members have known roles in cancer pointing to a potential link. Its functions tie to disorders associated with genomic instability possibly connecting with mutagenic activities leading to oncogenesis. Examination of APOBEC4 within cancer pathways involves looking at how APOBEC3 proteins also contribute to tumorigenesis hinting at a shared mechanistic influence across this protein family.
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Specifications

Form

Liquid

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General info

Function

Putative C to U editing enzyme whose physiological substrate is not yet known.

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

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Product protocols

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Target data

Putative C to U editing enzyme whose physiological substrate is not yet known.
See full target information APOBEC4
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Product promise

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