Recombinant Human Apolipoprotein A V/APOA5 - BSA and Azide free (denatured)
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Recombinant Human Apolipoprotein A V/APOA5 - BSA and Azide free (denatured) is a Human Full Length protein, in the 24 to 366 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.
View Alternative Names
RAP3, UNQ411/PRO773, APOA5, Apolipoprotein A-V, Apo-AV, ApoA-V, Apolipoprotein A5, Regeneration-associated protein 3
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Apolipoprotein A V/APOA5 - BSA and Azide free (denatured) (AB174391)
SDS-PAGE analysis Apolipoprotein A V/APOA5 using 3 μg of ab174391 on a 15% gel.
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
APOA5 influences triglyceride metabolism and is part of the HDL particle complex. It interacts directly with lipoprotein lipase to promote the hydrolysis of triglycerides into free fatty acids. This hydrolytic action aids in reducing triglyceride levels in the plasma. APOA5 also indirectly influences very-low-density lipoprotein (VLDL) metabolism reinforcing its role in lipid regulation.
Pathways
APOA5 integrates into the lipoprotein metabolic pathway and the PPAR signaling pathway. In the lipoprotein metabolic pathway APOA5 works with proteins like APOC3 to influence triglyceride homeostasis. This protein is modulated by PPAR-alpha helping control lipid metabolism and energy homeostasis. Its role in these pathways highlights its impact on triglyceride-rich lipoprotein metabolism positioning it as an important player in maintaining lipid balance.
Specifications
Form
Liquid
Additional notes
ab174391 is purified using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography (Sephacryl S-200) with 20 mM Tris pH 7.5, 2 mM EDTA.
General info
Function
Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin : cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin (PubMed : 17326667).
Sequence similarities
Belongs to the apolipoprotein A1/A4/E family.
Post-translational modifications
Phosphorylated by FAM20C in the extracellular medium.
Subcellular localisation
Early endosome
Target data
Complementary Products
Product promise
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