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AB127827

Recombinant Human Apolipoprotein O like

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Recombinant Human Apolipoprotein O like is a Human Fragment protein, in the 27 to 192 aa range, expressed in Escherichia coli, with >50%, suitable for SDS-PAGE.

View Alternative Names

CXorf33, FAM121A, MIC27, UNQ8193/PRO23204, APOOL, MICOS complex subunit MIC27, Apolipoprotein O-like, Protein FAM121A

Key facts

Purity

>50% SDS-PAGE

Expression system

Escherichia coli

Tags

His-DHFR tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q6UXV4

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in 200 µL of water

Storage buffer

Constituents: 0.58% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"","proteinLength":"Fragment","predictedMolecularWeight":"18.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":192,"aminoAcidStart":27,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q6UXV4","tags":[{"tag":"His-DHFR","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Apolipoprotein O-like sometimes known simply as ApoOL plays a role in lipid metabolism. This protein has a mass of approximately 22 kDa and is expressed in various tissues including the liver and intestines which are vital for lipid processing. It contributes to the regulation of lipid transport and availability in cells interacting with lipid-containing particles such as lipoproteins.
Biological function summary

Apolipoprotein O-like influences lipid homeostasis and energy metabolism within the body. It does not function as a part of a larger complex but still interacts with other proteins involved in lipid regulation. Its role in the body involves maintaining proper lipid levels and ensuring energy is properly stored and utilized especially in tissues relying on lipids as an energy source.

Pathways

Apolipoprotein O-like is involved in the lipid metabolic pathway an essential process for maintaining cellular membrane integrity and energy storage. In this pathway it relates to other proteins like Apolipoprotein E which is critical for lipid transport and redistribution. ApoOL's function contributes to the overall balance of lipid levels across different cell types ensuring metabolic needs are met consistently and efficiently.

Apolipoprotein O-like shows connections to conditions such as dyslipidemia and cardiovascular disease. Changes in its expression or function may alter lipid levels implicating it in the development of these conditions. In the context of cardiovascular disease ApoOL's interactions with proteins like Apolipoprotein B suggest its contribution to lipid abnormalities that influence heart health.
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Specifications

Form

Lyophilized

Additional notes

Purified via His tag

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General info

Function

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed : 23704930), (PubMed : 25764979).

Sequence similarities

Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.

Subcellular localisation

Mitochondrion inner membrane

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Product protocols

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Target data

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed : 23704930), (PubMed : 25764979).
See full target information APOOL
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Product promise

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