Recombinant Human Aquaporin 1 protein is a Human Full Length protein, in the 1 to 269 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
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- Nature communications 9:12542018Fluorescent label-free quantitative detection of nano-sized bioparticles using a pillar array.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKerwin Kwek Zeming et. al.PubMed 29593276
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M A S E F K K K L F W R A V V A E F L A T T L F V F I S I G S A L G F K Y P V G N N Q T A V Q D N V K V S L A F G L S I A T L A Q S V G H I S G A H L N P A V T L G L L L S C Q I S I F R A L M Y I I A Q C V G A I V A T A I L S G I T S S L T G N S L G R N D L A D G V N S G Q G L G I E I I G T L Q L V L C V L A T T D R R R R D L G G S A P L A I G L S V A L G H L L A I D Y T G C G I N P A R S F G S A V I T H N F S N H W I F W V G P F I G G A L A V L I Y D F I L A P R S S D L T D R V K V W T S G Q V E E Y D L D A D D I N S R V E M K P K
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:1373524, PubMed:23219802). Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2) (PubMed:16682607, PubMed:17012249, PubMed:19273840, PubMed:33028705, PubMed:8584435). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol (PubMed:17012249, PubMed:35835865). In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (PubMed:36949749, PubMed:8703053).
Alternative names
CHIP28, AQP1, Aquaporin-1, AQP-1, Aquaporin-CHIP, Channel-like integral membrane protein of 28 kDa, Urine water channel
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Recombinant Human Aquaporin 1 protein is a Human Full Length protein, in the 1 to 269 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- Tag free
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- P29972-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.3% Glutathione
Sequence info
Amino acid sequence
- M A S E F K K K L F W R A V V A E F L A T T L F V F I S I G S A L G F K Y P V G N N Q T A V Q D N V K V S L A F G L S I A T L A Q S V G H I S G A H L N P A V T L G L L L S C Q I S I F R A L M Y I I A Q C V G A I V A T A I L S G I T S S L T G N S L G R N D L A D G V N S G Q G L G I E I I G T L Q L V L C V L A T T D R R R R D L G G S A P L A I G L S V A L G H L L A I D Y T G C G I N P A R S F G S A V I T H N F S N H W I F W V G P F I G G A L A V L I Y D F I L A P R S S D L T D R V K V W T S G Q V E E Y D L D A D D I N S R V E M K P K
- Accession
- P29972
- Protein length
- Full Length
- Predicted molecular weight
- 55.7 kDa
- Amino acids
- 1 to 269
- Nature
- Recombinant
Specifications
- Form
- Liquid
General info
- Function
Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:1373524, PubMed:23219802). Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2) (PubMed:16682607, PubMed:17012249, PubMed:19273840, PubMed:33028705, PubMed:8584435). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol (PubMed:17012249, PubMed:35835865). In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (PubMed:36949749, PubMed:8703053).
- Sequence similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Aquaporin 1 also known as Aquaporin-1 AQP-1 or AQP1 is a protein that functions as a water channel facilitating the transport of water across cell membranes. This protein plays an important role in maintaining water homeostasis within cells. Aquaporin 1 has a mass of approximately 28 kDa and is encoded by the AQP1 gene. It is expressed in various tissues and organs including the kidneys lungs and red blood cells indicating its importance in diverse physiological processes.
- Biological function summary
Aquaporin 1 is not part of a complex but independently contributes to maintaining osmotic balance and fluid movement across epithelial and endothelial tissues. The protein's selective permeability for water without allowing ions or other solutes highlights its specificity in controlling water transport which is essential for maintaining cellular environment stability.
- Pathways
The aquaporin protein is involved in key biological pathways such as the osmoregulatory pathway and the fluid secretion pathway. It maintains efficient water transport in processes like urine concentration in the kidneys and fluid regulation in the pulmonary system. Aquaporins in general are related to similar transport proteins like sodium channels which together play an important role in maintaining osmotic balance across various tissues.
- Associated diseases and disorders
Aquaporin 1's dysfunction has been associated with conditions such as nephrogenic diabetes insipidus and pulmonary edema. These are linked to its role in water reabsorption in the kidneys and fluid balance in the lungs. The disorder's connection ties Aquaporin-1 with other regulatory proteins such as vasopressin receptors which work in conjunction to control renal water reabsorption and response to fluid imbalance.
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SDS-PAGE - Recombinant Human Aquaporin 1 protein (ab114210)
12.5% SDS-PAGE analysis of ab114210 stained with Coomassie Blue.
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