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AB157901

Recombinant Human Aquaporin 7 protein

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Recombinant Human Aquaporin 7 protein is a Human Full Length protein, in the 1 to 342 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

AQP7L, AQP9, AQP7, Aquaporin-7, AQP-7, Aquaglyceroporin-7, Aquaporin adipose, Aquaporin-7-like, AQPap

1 Images
SDS-PAGE - Recombinant Human Aquaporin 7 protein (AB157901)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Aquaporin 7 protein (AB157901)

ab157901 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

O14520

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MVQASGHRRSTRGSKMVSWSVIAKIQEILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVLNKKYGSYLGVNLGFGFGVTMGVHVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQFLGSFLAAATIYSLFYTAILHFSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTGMLQLCLFAITDQENNPALPGTEALVIGILVVIIGVSLGMNTGYAINPSRDLPPRIFTFIAGWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGSTIPREPLKLEDSVAYEDHGITVLPKMGSHEPTISPLTPVSVSPANRSSVHPAPPLHESMALEHF","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":342,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O14520","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Aquaporin 7 (AQP7) sometimes referred to as AQPap is a protein channel that enables the transport of water and small molecules like glycerol across cell membranes. It has a molecular mass of approximately 28 kDa. This protein is widely expressed in adipose tissue kidney and testis where it facilitates critical cellular processes by regulating water and solute flow. The localization of AQP7 in these tissues highlights its key role in the body’s fluid management and metabolic regulation.
Biological function summary

AQP7 plays an important role in maintaining the balance of glycerol and water within cells which is essential for energy homeostasis. It does not function as part of a known complex but works as an individual tetrameric channel. In adipose tissue AQP7 facilitates the release of glycerol consequently affecting lipid metabolism and energy storage. This function contributes significantly to how organisms respond to energy demands and metabolic changes.

Pathways

AQP7 is critical in glycerol transport and lipid metabolism pathways impacting insulin signaling and glucose regulation. AQP7 is closely associated with proteins like adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) which regulate lipid breakdown and mobilization. The interplay between these proteins and AQP7 illustrates its importance in pathways that govern energy balance and metabolic flexibility affecting how cells use stored energy.

AQP7 has associations with metabolic conditions such as obesity and type 2 diabetes. Altered expression or functionality of AQP7 in adipose tissue can influence glycerol release and consequently lipid and glucose metabolism. Dysregulation of AQP7 may also impact metabolic processes by interacting with proteins involved in lipid metabolism like ATGL and HSL. These connections highlight the significance of AQP7 in understanding the molecular basis of metabolic diseases.
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Specifications

Form

Liquid

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General info

Function

Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed : 11952783, PubMed : 30420639, PubMed : 30423801, PubMed : 36737436, PubMed : 9405233). Could also be permeable to urea (PubMed : 9405233). Mediates the efflux of glycerol, formed upon triglyceride hydrolysis, to avoid its accumulation in adipocytes and to make it available to other tissues. In the kidney, mediates the reabsorption of glycerol, preventing its loss in urine, again participating to energy homeostasis. In pancreatic beta cells, it also mediates the efflux of glycerol, regulating its intracellular levels (By similarity).

Sequence similarities

Belongs to the MIP/aquaporin (TC 1.A.8) family.

Post-translational modifications

Phosphorylation by PKA could prevent the interaction with PLIN1.

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Product protocols

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Target data

Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed : 11952783, PubMed : 30420639, PubMed : 30423801, PubMed : 36737436, PubMed : 9405233). Could also be permeable to urea (PubMed : 9405233). Mediates the efflux of glycerol, formed upon triglyceride hydrolysis, to avoid its accumulation in adipocytes and to make it available to other tissues. In the kidney, mediates the reabsorption of glycerol, preventing its loss in urine, again participating to energy homeostasis. In pancreatic beta cells, it also mediates the efflux of glycerol, regulating its intracellular levels (By similarity).
See full target information AQP7
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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

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