Recombinant Human ARD1A protein
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Recombinant Human ARD1A protein is a Human Full Length protein, in the 1 to 235 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
ARD1, ARD1A, TE2, NAA10, N-alpha-acetyltransferase 10, N-terminal acetyltransferase complex ARD1 subunit homolog A, NatA catalytic subunit Naa10, hARD1
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human ARD1A protein (AB113135)
15% SDS-PAGE analysis of 3 μg ab113135.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Acetylation by ARD1A modulates protein interactions and function. The NatA complex where ARD1A acts influences processes including cell cycle regulation and apoptosis. By modifying substrates critical for cell fate ARD1A plays a role in maintaining cellular balance. This complex helps in modifying proteins like actin which regulates the cytoskeleton a cellular structure essential for movement and division.
Pathways
Protein acetylation by ARD1A fits into the cellular signaling and protein degradation pathways. The complex alters substrates involved in proteasome-mediated degradation relating it to ubiquitin-proteasome pathways. Other interactions include the modulation of gene expression pathways impacting proteins like histones which are core to chromatin structure and gene regulation.
Specifications
Form
Liquid
Additional notes
ab113135 was purified by using conventional chromatography techniques.
General info
Function
Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (PubMed : 15496142, PubMed : 19420222, PubMed : 19826488, PubMed : 20145209, PubMed : 20154145, PubMed : 25489052, PubMed : 27708256, PubMed : 29754825, PubMed : 32042062). Acetylates amino termini that are devoid of initiator methionine (PubMed : 19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed : 12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed : 19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed : 20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed : 27708256). Acetylates HIST1H4A (PubMed : 29754825). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed : 27422821).
Sequence similarities
Belongs to the acetyltransferase family. ARD1 subfamily.
Post-translational modifications
Cleaved by caspases during apoptosis.. Phosphorylation by IKBKB/IKKB at Ser-209 promotes its proteasome-mediated degradation.. Autoacetylated at Lys-136 which stimulates its catalytic activity.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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