Recombinant Human ARF3 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The functions performed by ARF3 revolve around the regulation of vesicle formation and trafficking within cells. It is critical in the formation of COPI-coated vesicles and is involved in the retrieval pathway of membrane proteins between the Golgi and endoplasmic reticulum. ARF3 interacts closely with proteins like coatomer and ARF-GEFs (guanine nucleotide exchange factors) to facilitate these processes. As part of its biological activity ARF3 affects the recruitment of various effector proteins necessary for the vesicular transport.

Pathways

ARF3 plays significant roles in the regulation of intracellular transport pathways and lipid signaling pathways. It interacts with proteins involved in the phosphatidylinositol signaling pathway influencing membrane dynamics and cell signaling. ARF3's function aligns it closely with proteins such as phosphatidylinositol 4-kinases which are key in modifying phosphoinositides that are essential for membrane trafficking and signal transduction.