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AB132846

Recombinant Human ARHGAP17 protein (GST tag N-Terminus)

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Recombinant Human ARHGAP17 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 881 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

RICH1, MSTP066, MSTP110, ARHGAP17, Rho GTPase-activating protein 17, Rho-type GTPase-activating protein 17, RhoGAP interacting with CIP4 homologs protein 1, RICH-1

1 Images
SDS-PAGE - Recombinant Human ARHGAP17 protein (GST tag N-Terminus) (AB132846)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ARHGAP17 protein (GST tag N-Terminus) (AB132846)

12.5% SDS-PAGE analysis of ab132846 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, SDS-PAGE, WB

applications

Biologically active

No

Accession

Q68EM7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB74454

Anti-ARHGAP17 antibody

Western blot - Anti-ARHGAP17 antibody (AB74454)

  • 4
  • 1
Primary Antibodies

AB188329

Anti-TXNDC11/EFP1 antibody [EPR14314] - C-terminal

RabMAb|Recombinant

Immunoprecipitation - Anti-TXNDC11/EFP1 antibody [EPR14314] - C-terminal (AB188329)

  • 0
  • 0
Proteins & Peptides

AB114626

Recombinant Human KPNA4 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human KPNA4 protein (GST tag N-Terminus) (AB114626)

  • 0
  • 0
Primary Antibodies

AB246925

Anti-DPH4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DPH4 antibody (AB246925)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGTDAERRHKKLPLTALAQNMQEASTQLEDSLLGKMLETCGDAENQLALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLVKKESFGVKLMDFQAHRRGGTLNRKHISPAFQPPLPPTDGSTVVPAGPEPPPQSSRAESSSGGGTVPSSAGILEQGPSPGDGSPPKPKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPQPPGVHSAGDSSLTNTAPTASKIVTDSNSRVSEPHRSIFPEMHSDSASKDVPGRILLDIDNDTESTAL","proteinLength":"Full Length","predictedMolecularWeight":"121.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":881,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q68EM7","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ARHGAP17 also known as Rho GTPase-activating protein 17 or by its popular alternate name Rich1 plays a significant role in regulating the Rho GTPase signaling pathway. It belongs to a group of proteins that convert active GTP-bound Rho GTPases to their inactive GDP-bound state. ARHGAP17 has a molecular weight of approximately 82 kDa. It is expressed in various tissues including the brain and the endothelial cells indicating its importance in diverse cellular environments.
Biological function summary

ARHGAP17 participates in cellular processes that require regulation of the actin cytoskeleton. It forms part of a larger complex that controls cell shape and movement by modulating cytoskeletal dynamics. By converting GTP-bound RhoA to its GDP-bound form ARHGAP17 directly affects cell morphology and polarity impacting processes like cell migration and adhesion.

Pathways

ARHGAP17 is actively involved in the Rho GTPase cycle which is critical for actin cytoskeleton reorganization. It intersects with the tight junction pathway where it influences cell-cell adhesion and maintains epithelial cell integrity. ARHGAP17 interacts with proteins such as Cdc42 enhancing its capacity to regulate cellular architecture and function within these pathways.

ARHGAP17 has been associated with conditions like cancer and cardiovascular disease. Aberrant expression or mutations of ARHGAP17 can lead to disruptions in cell polarity and uncontrolled cell proliferation contributing to tumor development. Moreover its role in maintaining endothelial cell junctions links it to cardiovascular disorders where it interacts with proteins like VE-cadherin to regulate vascular integrity.
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Specifications

Form

Liquid

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General info

Function

Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.

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Product protocols

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Target data

Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.
See full target information ARHGAP17
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