Recombinant Human ARHGEF7 protein (His-DHFR tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ARHGEF7 also known as beta-PIX or Cool-1 is a guanine nucleotide exchange factor (GEF) involved in activating Rho GTPases specifically Rac1 and Cdc42. The protein plays a critical role in signal transduction by facilitating the exchange of GDP for GTP on these small GTPases leading to changes in cell morphology and motility. ARHGEF7 has a molecular mass of approximately 82 kDa and is widely expressed in various tissues including the brain and lungs. It commonly finds expression in neurons and plays a significant role in cytoskeletal dynamics.

Biological function summary

ARHGEF7 contributes to cell adhesion migration and synaptic plasticity. It interacts with other cytoskeletal-associated proteins forming complexes that regulate actin cytoskeleton organization. In neuronal cells ARHGEF7 is essential for dendritic spine formation and synapse maintenance facilitating neurotransmission and neural connectivity. Through its role in modulating actin dynamics ARHGEF7 influences cellular protrusions essential for communication between cells.

Pathways

ARHGEF7 plays a significant role in pathways controlling cell migration and signaling. It interacts within the Rac1 and Cdc42 pathways pivotal in reorganizing the actin cytoskeleton and forming cellular protrusions such as filopodia and lamellipodia. ARHGEF7 links functionally with proteins like PAK kinases that modulate cell movement and signaling pathways. These pathways collectively contribute to cellular communication and tissue structuring.

ARHGEF7 connections exist with neurological disorders such as intellectual disability and autism spectrum disorders. Dysregulation of ARHGEF7 disrupts synaptic function and neural architecture which can result in cognitive and developmental deficits. Additionally ARHGEF7 interacts with proteins like DISC1 influencing psychiatric conditions. The precise role of ARHGEF7 in these disorders requires further investigation to fully understand its therapeutic implications.