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AB109953

Recombinant Human ARL11 protein

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Recombinant Human ARL11 protein is a Human Full Length protein, in the 1 to 196 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

ARLTS1, ARL11, ADP-ribosylation factor-like protein 11, ADP-ribosylation factor-like tumor suppressor protein 1

1 Images
SDS-PAGE - Recombinant Human ARL11 protein (AB109953)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ARL11 protein (AB109953)

15% SDS-PAGE analysis of ab109953 (3μg)

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q969Q4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.08% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.03% EDTA

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSVNSRGHKAEAQVVMMGLDSAGKTTLLYKLKGHQLVETLPTVGFNVEPLKAPGHVSLTLWDVGGQAPLRASWKDYLEGTDILVYVLDSTDEARLPESAAELTEVLNDPNMAGVPFLVLANKQEAPDALPLLKIRNRLSLERFQDHCWELRGCSALTGEGLPEALQSLWSLLKSRSCMCLQARAHGAERGDSKRS","proteinLength":"Full Length","predictedMolecularWeight":"23.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":196,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q969Q4","tags":[{"tag":"His","terminus":"N-Terminus"}]}]

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ARL11 also known as ADP-ribosylation factor-like 11 is a small GTPase protein involved in cellular processes such as vesicle trafficking and signal transduction. This protein has a mass of approximately 20 kilodaltons. ARL11 is expressed in various tissues with notable levels in the pancreas spleen and peripheral blood leukocytes. Researchers frequently study this target due to its role in cellular mechanics and its diverse tissue expression pattern.
Biological function summary

ARL11 regulates cell growth and apoptosis influencing the cellular response to stress. This protein often functions as part of molecular complexes interacting with elements of the cellular machinery to modulate the cell cycle and cellular proliferation. Through these interactions ARL11 can impact the integrity and functionality of cellular processes which positions it as a point of interest in understanding cell regulation and stress responses.

Pathways

ARL11 plays roles in both the apoptosis and signal transduction pathways. It interacts with proteins such as p53 and other members of the Ras superfamily which are involved in controlling cell cycle progression and apoptosis. These pathways highlight ARL11's involvement in maintaining proper cellular function and response to external and internal signals linking it to broader cellular activity networks.

Researchers associate ARL11 with certain types of cancers including pancreatic cancer and lymphomas. Its interaction with proteins like p53 suggests a role in tumor suppression and regulation of cell cycle checkpoints. Changes in ARL11 function or expression may contribute to oncogenic processes suggesting its potential as a target for therapeutic interventions in cancer treatments.

Specifications

Form

Liquid

Additional notes

ab109953 was purified using conventional chromatography techniques

General info

Function

May play a role in apoptosis. May act as a tumor suppressor.

Sequence similarities

Belongs to the small GTPase superfamily. Arf family.

Product protocols

Target data

May play a role in apoptosis. May act as a tumor suppressor.
See full target information ARL11

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