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AB113118

Recombinant Human ARL15 protein

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(1 Publication)

Recombinant Human ARL15 protein is a Human Full Length protein, in the 1 to 204 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

ARFRP2, ARL15, ADP-ribosylation factor-like protein 15, ADP-ribosylation factor-related protein 2, ARF-related protein 2

1 Images
SDS-PAGE - Recombinant Human ARL15 protein (AB113118)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ARL15 protein (AB113118)

15% SDS-PAGE analysis of 3 µg ab113118.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9NXU5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMSDLRITEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPDNVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLEAARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEIKKYFELEPLARGKRWILQPCSLDDMDALKDSFSQLINLLEEKDHEAVRM","proteinLength":"Full Length","predictedMolecularWeight":"25 kDa","actualMolecularWeight":null,"aminoAcidEnd":204,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NXU5","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ARL15 also known as ADP-ribosylation factor-like protein 15 is a member of the ARF family of GTPases. This small GTP-binding protein weighs about 21 kDa. ARL15 resides mainly in the cytoplasm but its expression is also notable in adipose tissue and the pancreas. Mechanical interaction of ARL15 with membranes and other molecules is characteristic for proteins in the ARF family indicating a role in cellular functions that involve vesicle trafficking or membrane remodeling.
Biological function summary

ARL15 influences metabolic processes and signaling pathways. It integrates into multiprotein complexes that regulate various cellular activities. Research suggests its involvement in lipid metabolism and adipogenesis playing a role in the regulation of insulin sensitivity. These biological functions make ARL15 significant for maintaining cellular energy balance and metabolic homeostasis.

Pathways

ARL15 engages with two central pathways: the insulin signaling pathway and lipid metabolism. It influences these pathways by interacting with key proteins such as IRS1 in insulin signaling which impacts glucose uptake and energy regulation. Additionally in lipid metabolism ARL15 associates with proteins that control fatty acid oxidation and storage contributing to the overall lipid balance within the cell.

ARL15 has connections to type 2 diabetes and obesity. People with altered expression levels of ARL15 often exhibit changes in insulin sensitivity linking it to the pathophysiology of type 2 diabetes. ARL15 also interacts with PPARγ a protein highly involved in fat tissue development and implicated in obesity. These interactions indicate potential pathways through which ARL15 influences metabolic conditions making it a target of interest for disease research.
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Specifications

Form

Liquid

Additional notes

ab113118 is purified using conventional chromatography techniques.

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General info

Sequence similarities

Belongs to the small GTPase superfamily. Arf family.

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Product protocols

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Target data

See full target information ARL15
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37:e23211 PubMed37773757

2023

Cleft palate and minor metabolic disturbances in a mouse global Arl15 gene knockout.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Bai,Liz Bentley,Chao Ma,Navaratnam Naveenan,James Cleak,Yixing Wu,Michelle M Simon,Henrik Westerberg,Ramón Casero Cañas,Neil Horner,Rajesh Pandey,Keanu Paphiti,Ulrike Schulze,Joffrey Mianné,Tertius Hough,Lydia Teboul,Jeroen H F de Baaij,Roger D Cox
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