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AB109841

Recombinant Human ARL4A protein

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Recombinant Human ARL4A protein is a Human Full Length protein, in the 1 to 200 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

ARL4, ARL4A, ADP-ribosylation factor-like protein 4A

1 Images
SDS-PAGE - Recombinant Human ARL4A protein (AB109841)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ARL4A protein (AB109841)

SDS-PAGE of ab109841 (3µg) under reducing condition and visualized by coomassie blue stain.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

P40617

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGNGLSDQTSILSNLPSFQSFHIVILGLDCAGKTTVLYRLQFNEFVNTVPTKGFNTEKIKVTLGNSKTVTFHFWDVGGQEKLRPLWKSYTRCTDGIVFVVDSVDVERMEEAKTELHKITRISENQGVPVLIVANKQDLRNSLSLSEIEKLLAMGELSSSTPWHLQPTCAIIGDGLKEGLEKLHDMIIKRRKMLRQQKKKR","proteinLength":"Full Length","predictedMolecularWeight":"24.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":200,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P40617","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ARL4A (ADP-Ribosylation Factor-Like 4A) acts as a small GTPase in the ADP-ribosylation factor family. This protein also known as ARF-like protein has a mass of approximately 20 kDa. ARL4A is expressed in various tissues including the brain and kidneys. It plays an important role in intracellular signaling impacting cytoskeleton dynamics and membrane trafficking.
Biological function summary

ARL4A impacts cellular processes through its involvement in actin cytoskeleton reorganization. This makes ARL4A important in cell migration and morphogenesis. As part of the ARF family ARL4A may interact with other small GTPases forming a signaling complex that modulates cellular function. Its activity helps maintain cell structure and movement reflecting its influence on morphogenetic processes.

Pathways

ARL4A participates in signal transduction networks like the Ras-related pathways. It links to proteins such as ARF6 showing its involvement in vesicular trafficking and cytoskeleton remodeling. Through these pathways ARL4A helps coordinate intracellular activities that maintain cell shape and adhesion contributing to overall cellular dynamics.

ARL4A links to pathological conditions like cancer and metabolic disorders. Abnormal ARL4A expression associates with oncogenic processes suggesting its influence on tumorigenesis. Additionally disruptions in ARL4A function might involve interactions with proteins like ARL6 indicating potential metabolic dysregulation. These connections highlight ARL4A's significance in disease development and progression marking it as an important target in disease research.
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Specifications

Form

Liquid

Additional notes

ab109841 is purified using conventional chromatography techniques.

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General info

Function

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.

Sequence similarities

Belongs to the small GTPase superfamily. Arf family.

Post-translational modifications

Myristoylated.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.
See full target information ARL4A
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