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AB113130

Recombinant Human ARL4D protein

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Recombinant Human ARL4D protein is a Human Full Length protein, in the 1 to 201 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

ARF4L, ARL4D, ADP-ribosylation factor-like protein 4D, ADP-ribosylation factor-like protein 4L

1 Images
SDS-PAGE - Recombinant Human ARL4D protein (AB113130)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ARL4D protein (AB113130)

15% SDS-PAGE analysis of 3 μg ab113130.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

P49703

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as ARF4L
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGNHLTEMAPTASSFLPHFQALHVVVIGLDSAGKTSLLYRLKFKEFVQSVPTKGFNTEKIRVPLGGSRGITFQVWDVGGQEKLRPLWRSYTRRTDGLVFVVDAAEAERLEEAKVELHRISRASDNQGVPVLVLANKQDQPGALSAAEVEKRLAVRELAAATLTHVQGCSAVDGLGLQQGLERLYEMILKRKKAARGGKKRR","proteinLength":"Full Length","predictedMolecularWeight":"24.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":201,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P49703","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ARL4D also known as ADP-ribosylation factor-like protein 4D is a small GTPase belonging to the ARF family. It has a molecular mass of approximately 22 kDa. Expression of ARL4D occurs in various tissues especially in the brain kidneys and testes. The protein localizes to the cytoplasm and often associates with the cell membrane. Its mechanical function includes the regulation of vesicular trafficking by cycling between active GTP-bound and inactive GDP-bound states.
Biological function summary

ARL4D plays a role in intracellular transport processes. It does not work alone but occasionally forms part of larger protein complexes influencing its activity and interaction capability. Its association with the actin cytoskeleton points towards a function in modifying cell shape and motility. Additionally ARL4D influences endocytic and exocytic pathways which are vital for protein sorting and nutrient uptake in cells.

Pathways

ARL4D interacts with structures related to the Wnt signaling and PI3K/AKT pathways. It influences the regulation of cell growth differentiation and survival through its interaction within these pathways. The ARL family proteins including ARL4A share overlapping roles and these proteins often modulate similar signaling circuits impacting cellular responses and environmental signals.

ARL4D associates with conditions affecting cellular transport and neurological function. Mutations or dysregulation of ARL4D have potential links to neurodegenerative diseases where protein trafficking is disrupted. Also its interaction with other GTPases like ARF6 suggests its role in certain cancers by influencing cellular signaling and tumor progression. Understanding ARL4D's function assists in revealing mechanisms behind these diseases allowing better-targeted therapeutic approaches.
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Specifications

Form

Liquid

Additional notes

ab113130 was purified using conventional chromatography techniques.

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General info

Function

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.

Sequence similarities

Belongs to the small GTPase superfamily. Arf family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form.
See full target information ARL4D
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Product promise

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