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AB101943

Recombinant Human ARL5A protein

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Recombinant Human ARL5A protein is a Human Full Length protein, in the 1 to 179 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

ARFLP5, ARL5, ARL5A, ADP-ribosylation factor-like protein 5A

1 Images
SDS-PAGE - Recombinant Human ARL5A protein (AB101943)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ARL5A protein (AB101943)

15% SDS-PAGE analysis of 3µg ab101943.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9Y689

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0308% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00348% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMGILFTRIWRLFNHQEHKVIIVGLDNAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNTRFLMWDIGGQESLRSSWNTYYTNTEFVIVVVDSTDRERISVTREELYKMLAHEDLRKAGLLIFANKQDVKECMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR","proteinLength":"Full Length","predictedMolecularWeight":"23.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":179,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9Y689","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ARL5A also known as ADP-ribosylation factor-like protein 5A is a membrane-associated small GTPase with a molecular mass of approximately 21 kDa. It belongs to the ARF family involved in vesicular trafficking and signaling processes. ARL5A is expressed in various tissues with higher expression in brain and testis. The protein exhibits a GTP-binding with intrinsic GTPase activity playing an important role in the regulation of intracellular vesicle transport.
Biological function summary

ARL5A functions as part of a larger molecular complex. The protein participates in endosomal trafficking processes and is associated with the Golgi apparatus. By modulating the dynamics of the Golgi-endosome transport system ARL5A influences vesicle budding and cargo sorting. It interacts with other proteins such as ARL5B to facilitate the formation and movement of vesicles in the cell.

Pathways

This protein participates in the intracellular trafficking-related signaling pathways. It plays a part in the Wnt signaling pathway influencing vesicular movement between organelles. ARL5A interacts with proteins like GGA proteins which are adaptors that mediate cargo sorting and potentially links it with other important regulators in these pathways. This interaction allows cells to maintain homeostasis and properly respond to signaling events.

Mutant ARL5A has associations with neurodevelopmental disorders pointing to its significance in neural development. The protein's aberrant functions can disrupt normal cellular mechanisms contributing to disease states. It connects with proteins like ARF6 also a member of the ARF family which are implicated in the same regulatory networks. Understanding ARL5A's roles in these conditions could provide insights into potential therapeutic targets.
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Specifications

Form

Liquid

Additional notes

ab101943 is purified using conventional chromatography techniques.

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General info

Function

Lacks ADP-ribosylation enhancing activity.

Sequence similarities

Belongs to the small GTPase superfamily. Arf family.

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Product protocols

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Target data

Lacks ADP-ribosylation enhancing activity.
See full target information ARL5A
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Product promise

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