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AB113159

Recombinant Human ARL5B protein

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Recombinant Human ARL5B protein is a Human Full Length protein, in the 1 to 299 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

ARL8, ARL5B, ADP-ribosylation factor-like protein 5B, ADP-ribosylation factor-like protein 8

1 Images
SDS-PAGE - Recombinant Human ARL5B protein (AB113159)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human ARL5B protein (AB113159)

ab113159 at 3 μg analysed by 15% SDS PAGE.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q96KC2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.04% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.03% EDTA

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGLIFAKLWSLFCNQEHKVIIVGLDNAGKTTILYQFLMNEVVHTSPTIGSNVEEIVVKNTHFLMWDIGGQESLRSSWNTYYSNTEFIILVVDSIDRERLAITKEELYRMLAHEDLRKAAVLIFANKQDMKGCMTAAEISKYLTLSSIKDHPWHIQSCCALTGEGLCQGLEWMTSRIGVR","proteinLength":"Full Length","predictedMolecularWeight":"22.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":299,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q96KC2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ARL5B also known as ADP-ribosylation factor-like protein 5B is a member of the ARL family of small GTP-binding proteins. It has a molecular mass of approximately 21 kDa. This protein localizes to the Golgi apparatus and endosomes indicating its role in intracellular trafficking. In various cell types ARL5B expression varies but it is notably present in high quantities in cells with dynamic membrane traffic and secretion functions.
Biological function summary

ARL5B assists in regulating vesicular transport and membrane dynamics ensuring the proper distribution of proteins and lipids within the cell. This protein interacts with effector proteins that aid its function and may form complexes with other GTPase proteins. By controlling vesicle formation and movement ARL5B plays a fundamental role in maintaining cellular organization and function.

Pathways

ARL5B involves itself in cellular trafficking pathways such as the endocytic recycling and secretory pathways. It functions in close relation to proteins like Rab families and other ARF family members. These collaborations aid in maintaining homeostasis of the cell surface receptor presentation and recycling having impacts on overall cellular signaling.

Alterations in ARL5B have associations with neurodegenerative diseases and certain cancers. Research indicates that it may interact with proteins like Rab7 linking it to pathways implicated in neuronal degeneration. Likewise its overexpression or misregulation could contribute to oncogenic processes possibly affecting proteins such as E-cadherin a critical adhesion protein in cancer progression.
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Specifications

Form

Liquid

Additional notes

ab113159 was purified by using conventional chromatography techniques.

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General info

Function

Binds and exchanges GTP and GDP.

Sequence similarities

Belongs to the small GTPase superfamily. Arf family.

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Product protocols

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Target data

Binds and exchanges GTP and GDP.
See full target information ARL5B
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