Recombinant Human ARL9 protein is a Human Full Length protein, in the 1 to 123 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M E F L E I G G S K P F R S Y W E M Y L S K G L L L I F V V D S A D H S R L P E A K K Y L H Q L I A A N P V L P L V V F A N K Q D L E A A Y H I T D I H E A L A L S E V G N D R K M F L F G T Y L T K N G S E I P S T M Q D A K D L I A Q L A A D V Q
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Alternative names
ADP-ribosylation factor-like protein 9, ARL9
Recommended products
Recombinant Human ARL9 protein is a Human Full Length protein, in the 1 to 123 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q6T311-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M E F L E I G G S K P F R S Y W E M Y L S K G L L L I F V V D S A D H S R L P E A K K Y L H Q L I A A N P V L P L V V F A N K Q D L E A A Y H I T D I H E A L A L S E V G N D R K M F L F G T Y L T K N G S E I P S T M Q D A K D L I A Q L A A D V Q
- Accession
- Q6T311
- Protein length
- Full Length
- Predicted molecular weight
- 15.9 kDa
- Amino acids
- 1 to 123
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab123161 purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
General info
- Sequence similarities
Belongs to the small GTPase superfamily. Arf family.
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ARL9 also known as ADP-ribosylation factor-like protein 9 is a small GTP-binding protein with a molecular weight of approximately 22 kDa. It belongs to the ARF family which is involved in regulating membrane traffic and organelle structure. ARL9 is expressed in various tissues but particularly abundant in the brain and kidneys. It functions intracellularly primarily associated with the Golgi apparatus where it participates in protein transport and membrane dynamics.
- Biological function summary
ARL9 operates as a molecular switch cycling between GTP-bound active and GDP-bound inactive states. It is part of a dynamic complex responsible for vesicle formation and protein trafficking within the Golgi and endosomal systems. This protein plays a significant role in the assembly and disassembly of coat protein complex II (COPII) vesicles which are essential for the transfer of proteins from the endoplasmic reticulum to the Golgi. The molecular machinery involving ARL9 modulates several cellular processes through its interaction with effectors and regulatory proteins.
- Pathways
ARL9 is linked to important cellular processes such as the Golgi-to-plasma membrane transport and the citric acid cycle. Its involvement in the secretory pathway is moderated by interactions with other proteins such as ADP-ribosylation factors and other ARL family members. ARL9 influences membrane trafficking events and aligns cellular metabolism with the needs of vesicular transport. The protein integrates signals for cellular dynamics which are important for maintaining cellular homeostasis through these pathways.
- Associated diseases and disorders
ARL9 holds relevance in neurodegenerative diseases and cancer. Researchers have noted its increased expression in neurological disorders suggesting a link to synaptic function and neural communication. Additionally ARL9 has associations with certain types of cancer due to its role in cellular proliferation and survival pathways. Proteins interacting with ARL9 in these contexts include altered signaling molecules related to cell growth and neuronal maintenance which suggests ARL9's participation in these disease mechanisms.
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1 product image
SDS-PAGE - Recombinant Human ARL9 protein (ab123161)
15% SDS PAGE analysis of 3 μg of Human ARL9 protein (ab123161).
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