Recombinant Human ARMS2 protein (denatured) (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ARMS2 protein also known as age-related maculopathy susceptibility 2 is a small protein with a molecular mass of around 12 kDa. Scientists find ARMS2 expressed particularly in the retina specifically in the photoreceptor layer. Its cellular presence suggests its involvement in retinal health and function though its precise cellular mechanisms are yet to be comprehensively understood indicating an area for further research.

Biological function summary

ARMS2 interacts with other cellular components to support retinal structure and function. Although ARMS2 is not confirmed as part of a larger protein complex it is suspected to play a role in the maintenance of extracellular matrix stability in the retina. This stability may help protect against changes in retinal cell organization and health relevant to visual processes.

Pathways

ARMS2 is implicated in pathways connected to cellular homeostasis and extracellular matrix regulation in the retina. While the precise pathways involving ARMS2 remain under investigation a noted association exists with complement system pathways. It has relationships with proteins like CFH which is central to complement regulation and inflammation control.

ARMS2 is notably linked to age-related macular degeneration (AMD) a leading cause of vision loss. The association with AMD suggests interactions with proteins affecting retinal integrity such as CFH emphasizing the role of inflammation and extracellular matrix maintenance in the disease's onset and progression. Understanding ARMS2 and its interactions could provide insights into potential therapeutic targets for AMD.