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AB163587

Recombinant Human ARRDC3 protein (GST tag N-Terminus)

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Recombinant Human ARRDC3 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 414 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

KIAA1376, ARRDC3, Arrestin domain-containing protein 3, TBP-2-like inducible membrane protein, TLIMP

1 Images
SDS-PAGE - Recombinant Human ARRDC3 protein (GST tag N-Terminus) (AB163587)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ARRDC3 protein (GST tag N-Terminus) (AB163587)

ab163587 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q96B67

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB64817

Anti-ARRDC3 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ARRDC3 antibody (AB64817)

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Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

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Proteins & Peptides

AB162402

Recombinant Human Zinc finger protein 691 (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Zinc finger protein 691 (GST tag N-Terminus) (AB162402)

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Proteins & Peptides

AB161146

Recombinant Human BS69 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human BS69 protein (GST tag N-Terminus) (AB161146)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRWTESRNAGSNTAYTQNYTEEVEYFNHKDILIGHERDDDNSEEGFHTIHSGRHEYAFSFELPQTPLATSFEGRHGSVRYWVKAELHRPWLLPVKLKKEFTVFEHIDINTPSLLSPQAGTKEKTLCCWFCTSGPISLSAKIERKGYTPGESIQIFAEIENCSSRMVVPKAAIYQTQAFYAKGKMKEVKQLVANLRGESLSSGKTETWNGKLLKIPPVSPSILDCSIIRVEYSLMVYVDIPGAMDLFLNLPLVIGTIPLHPFGSRTSSVSSQCSMNMNWLSLSLPERPEAPPSYAEVVTEEQRRNNLAPVSACDDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":414,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q96B67","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ARRDC3 known as Arrestin Domain Containing 3 is a relatively small protein with a mass of about 47 kDa. It acts by regulating the internalization and degradation of specific seven-transmembrane receptors through endosomal pathways. ARRDC3 expresses widely in various tissues with higher expressions in the brain heart and skeletal muscle. The protein contains an arrestin domain and initiates interactions with other proteins in cellular signaling.
Biological function summary

ARRDC3 influences cellular communication and adapts cellular responses. As part of a complex that includes members of the NEDD4 family E3 ligases it influences ubiquitination processes. ARRDC3 modulates the degradation and downregulation of G-protein-coupled receptors (GPCRs) which plays an important role in maintaining cellular signaling dynamics. This regulation affects multiple cellular functions including receptor recycling and signal transduction efficiency.

Pathways

ARRDC3 prominently integrates into the ubiquitin-proteasome system and GPCR signaling pathways. It functions in pathways that manage receptor trafficking and desensitization. The protein interacts closely with β-arrestins which play significant roles in GPCR internalization. The coordination with these proteins ensures the proper signaling cascade and termination impacting overall pathway efficiency.

Alterations in ARRDC3 expression have implications for cancer and obesity. In certain cancers such as breast cancer altered ARRDC3 levels correlate with tumor progression and metastasis. The protein also associates with energy balance and body weight regulation linking its function to obesity. The interaction with β-arrestins in these disorders suggests a mechanism where disrupted receptor trafficking exacerbates these conditions.
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Specifications

Form

Liquid

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General info

Function

Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed : 20559325, PubMed : 21982743, PubMed : 23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed : 20559325, PubMed : 23208550). May recruit NEDD4 to ADRB2 (PubMed : 20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed : 23208550).

Sequence similarities

Belongs to the arrestin family.

Subcellular localisation

Lysosome

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Product protocols

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Target data

Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein-coupled receptors (PubMed : 20559325, PubMed : 21982743, PubMed : 23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed : 20559325, PubMed : 23208550). May recruit NEDD4 to ADRB2 (PubMed : 20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed : 23208550).
See full target information ARRDC3
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