Recombinant Human ASAM protein (His tag) is a Human Fragment protein, in the 1 to 233 aa range, expressed in HEK 293, with >97% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
>97% SDS-PAGE
< 1 EU/µg
HEK 293 cells
His tag C-Terminus
SDS-PAGE
No
M S L L L L L L L V S Y Y V G T L G T H T E I K R V A E E K V T L P C H H Q L G L P E K D T L D I E W L L T D N E G N Q K V V I T Y S S R H V Y N N L T E E Q K G R V A F A S N F L A G D A S L Q I E P L K P S D E G R Y T C K V K N S G R Y V W S H V I L K V L V R P S K P K C E L E G E L T E G S D L T L Q C E S S S G T E P I V Y Y W Q R I R E K E G E D E R L P P K S R I D Y N H P G R V L L Q N L T M S Y S G L Y Q C T A G N E A G K E S C V V R V T V Q Y V Q S I G M
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.
ACAM, ASAM, UNQ318/PRO363, CLMP, CXADR-like membrane protein, Adipocyte adhesion molecule, Coxsackie- and adenovirus receptor-like membrane protein, CAR-like membrane protein
Recombinant Human ASAM protein (His tag) is a Human Fragment protein, in the 1 to 233 aa range, expressed in HEK 293, with >97% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
>97% SDS-PAGE
< 1 EU/µg
HEK 293 cells
His tag C-Terminus
SDS-PAGE
No
No
Human
pH: 7.4
Constituents: 100% PBS
M S L L L L L L L V S Y Y V G T L G T H T E I K R V A E E K V T L P C H H Q L G L P E K D T L D I E W L L T D N E G N Q K V V I T Y S S R H V Y N N L T E E Q K G R V A F A S N F L A G D A S L Q I E P L K P S D E G R Y T C K V K N S G R Y V W S H V I L K V L V R P S K P K C E L E G E L T E G S D L T L Q C E S S S G T E P I V Y Y W Q R I R E K E G E D E R L P P K S R I D Y N H P G R V L L Q N L T M S Y S G L Y Q C T A G N E A G K E S C V V R V T V Q Y V Q S I G M
Fragment
25.8 kDa
1 to 233
Recombinant
His tag C-Terminus
Lyophilized
May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.
Ambient - Can Ship with Ice
-20°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This supplementary information is collated from multiple sources and compiled automatically.
The ASAM protein also known as the Adipocyte plasma Membrane Associated Protein (APPL1) is a transmembrane protein with a mass around 34 kDa. It is highly expressed in adipose tissue and endothelial cells but appears across a range of tissues. The ASAM protein plays a role in adhesion processes by facilitating cell-cell interactions and is important in maintaining cellular architecture. It interacts with multiple binding partners suggesting diverse functionality and involvement in cellular signaling pathways.
The ASAM protein has significant roles in cellular adhesion and signaling. As part of the plasma membrane it modulates interactions between cells and their environment contributing to tissue development and repair. It is not typically known to be part of a larger complex but its ability to bind with other proteins highlights its versatility in cellular regulation. Researchers understand it better in the context of cell structural dynamics and communication processes.
Research identifies the ASAM protein as a player in the insulin signaling pathway and the cellular adhesion pathway. In insulin signaling it interacts with proteins such as IGF1R and PI3K connecting it to metabolic regulation and homeostasis. The cellular adhesion pathway finds ASAM working with cadherins and integrins which emphasizes its function in cell communication and structural integrity. Its engagement in these pathways indicates its influence on metabolic processes and cellular response mechanisms.
The ASAM protein shows relevance in conditions like diabetes and obesity. Its involvement in insulin signaling aligns it with metabolic disorders where dysregulation affects glucose uptake and lipid metabolism. Histological studies indicate ASAM interactions with other proteins like FAK and AMPK in the context of these diseases. This connection suggests its potential as a biomarker for metabolic syndromes providing insight into disease development and therapeutic target exploration.
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SDS-PAGE analysis of ab276317
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