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AB171706

Recombinant Human ASB8 protein (His tag N-Terminus)

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Recombinant Human ASB8 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 288 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

PP14212, ASB8, Ankyrin repeat and SOCS box protein 8, ASB-8

1 Images
SDS-PAGE - Recombinant Human ASB8 protein (His tag N-Terminus) (AB171706)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ASB8 protein (His tag N-Terminus) (AB171706)

15% SDS-PAGE analysis of ab171706 (3μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9H765

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMSSSMWYIMQSIQSKYSLSERLIRTIAAIRSFPHDNVEDLIRGGADVNCTHGTLKPLHCACMVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVALLVRGLGTEKEDSCFELLHRAVGHFELRKNGTMPREVARDPQLCEKLTVLCSAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLLE","proteinLength":"Full Length","predictedMolecularWeight":"34 kDa","actualMolecularWeight":null,"aminoAcidEnd":288,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9H765","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ASB8 protein or Ankyrin Repeat and SOCS Box Containing 8 measures approximately 27 kDa in molecular mass. It functions mechanically as part of the SOCS box family which usually interacts with elongin BC complexes. ASB8 contributes to the ubiquitin-proteasome pathway by binding to substrate proteins targeting them for degradation. It is expressed in various human tissues including skeletal muscle and heart indicating its importance in those areas.
Biological function summary

The ASB8 protein modulates different cellular processes by influencing protein turnover. Though ASB8 does not appear as a member of a larger complex it often interacts with elongin B and C to form an E3 ubiquitin ligase complex. This complex facilitates the tagging of proteins with ubiquitin marking them for degradation via the proteasome. By regulating such degradation ASB8 plays roles in maintaining cellular function and homeostasis.

Pathways

ASB8 engages in the ubiquitin-proteasome pathway a significant player in protein quality control and cellular regulation. It also links with signaling pathways like the JAK-STAT pathway impacting cellular responses to external signals. ASB8 is associated with other proteins such as SOCS family members and elongin BC which work together to regulate these pathways. These interactions highlight the regulatory potential of ASB8 in cell signaling and protein turnover.

ASB8 shows connections to muscle-related conditions and cardiac disorders. Mutations or dysregulation of ASB8 could be implicated in muscle atrophy or cardiomyopathies due to its role in muscle and heart tissue. ASB8's involvement in protein degradation and signaling pathways makes it likely to interact with other SOCS family proteins during these disease processes indicating a complex network of interactions influencing disease progression.
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Specifications

Form

Liquid

Additional notes

ab171706 is purified using conventional chromatography techniques.

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General info

Function

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Sequence similarities

Belongs to the ankyrin SOCS box (ASB) family.

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Product protocols

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Target data

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
See full target information ASB8
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Complementary Products

Primary Antibodies

AB227475

Anti-ASB8 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ASB8 antibody (AB227475)

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