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AB171688

Recombinant Human ASCC1 protein (His tag N-Terminus)

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Recombinant Human ASCC1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 357 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

CGI-18, ASCC1, Activating signal cointegrator 1 complex subunit 1, ASC-1 complex subunit p50, Trip4 complex subunit p50

1 Images
SDS-PAGE - Recombinant Human ASCC1 protein (His tag N-Terminus) (AB171688)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ASCC1 protein (His tag N-Terminus) (AB171688)

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q8N9N2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMEVLRPQLIRIDGRNYRKNPVQEQTYQHEEDEEDFYQGSMECADEPCDAYEVEQTPQGFRSTLRAPSLLYKHIVGKRGDTRKKIEMETKTSISIPKPGQDGEIVITGQHRNGVISARTRIDVLLDTFRRKQPFTHFLAFFLNEVEVQEGFLRFQEEVLAKCSMDHGVDSSIFQNPKKLHLTIGMLVLLSEEEIQQTCEMLQQCKEEFINDISGGKPLEVEMAGIEYMNDDPGMVDVLYAKVHMKDGSNRLQELVDRVLERFQASGLIVKEWNSVKLHATVMNTLFRKDPNAEGRYNLYTAEGKYIFKERESFDGRNILKLFENFYFGSLKLNSIHISQRFTVDSFGNYASCGQIDFS","proteinLength":"Full Length","predictedMolecularWeight":"43.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":357,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8N9N2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ASCC1 also known as Activating Signal Cointegrator 1 Complex Subunit 1 serves as a part of an important protein complex involved in transcriptional regulation. This protein weighs approximately 86 kilodaltons and exhibits expression in various tissues including the heart and skeletal muscles. ASCC1 acts mechanically by contributing to the remodeling of chromatin assisting in the process of transcriptional activation by modifying how genes are accessed within the chromatin structure.
Biological function summary

ASCC1 plays an important role in the functioning of the ASC-1 complex which includes other associated subunits such as ASCC2 and ASCC3. This complex is involved in the regulation of gene expression by influencing the transcriptional machinery. Through interaction with transcriptional coactivators ASCC1 modulates the transcription of specific genes aiding in cellular response mechanisms.

Pathways

Researchers have identified ASCC1 as pivotal in the DNA repair process and the transcription-coupled nucleotide excision repair pathway. Within the DNA repair pathway ASCC1 collaborates with proteins such as XPC in addressing DNA damage and maintaining genomic stability. This integration into critical pathways illustrates its influence on cellular processes that protect the genomic integrity from various types of damage.

Scientists link mutations in ASCC1 to esophageal cancer and spinal muscular atrophy. In esophageal cancer altered ASCC1 expression influences tumorigenic pathways often in conjunction with proteins such as p53. Similarly dysfunction in spinal muscular atrophy involves protein partners where ASCC1 abnormalities disrupt normal cellular mechanisms resulting in the disease's characteristic symptoms. Understanding these connections offers potential insights into therapeutic approaches targeting ASCC1-related pathways.
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Specifications

Form

Liquid

Additional notes

ab171688 is purified using conventional chromatography techniques.

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General info

Function

Plays a role in DNA damage repair as component of the ASCC complex (PubMed : 29997253). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed : 12077347). In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Plays a role in DNA damage repair as component of the ASCC complex (PubMed : 29997253). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed : 12077347). In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.
See full target information ASCC1
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Complementary Products

Primary Antibodies

AB157102

Anti-ASCC1 antibody

Western blot - Anti-ASCC1 antibody (AB157102)

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