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AB157919

Recombinant Human ASIP protein (GST tag N-Terminus)

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Recombinant Human ASIP protein (GST tag N-Terminus) is a Human Fragment protein, in the 33 to 132 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

AGTI, AGTIL, ASP, ASIP, Agouti-signaling protein, Agouti switch protein

1 Images
SDS-PAGE - Recombinant Human ASIP protein (GST tag N-Terminus) (AB157919)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ASIP protein (GST tag N-Terminus) (AB157919)

ab157919 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

P42127

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Primary Antibodies

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"DRSLRSNSSVNLLDVPSVSIVALNKKSKQIGRKAAEKKRSSKKEASMKKVVRPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":132,"aminoAcidStart":33,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P42127","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The agouti signaling protein (ASIP) also known as agouti protein or agouti switch protein functions mechanically as an antagonist to the melanocortin 1 receptor (MC1R). This interaction influences pigmentation processes by modulating eumelanin and pheomelanin production. ASIP possesses a mass of approximately 14 kDa. It is expressed in several tissues such as skin adipose tissue and neural tissues highlighting its varied roles in different biological contexts.
Biological function summary

ASIP plays an important role in pigmentation regulation and energy homeostasis. It prevents MC1R from binding its ligand alpha-melanocyte-stimulating hormone (α-MSH) leading to lightening of skin and fur coloration by shifting melanin production from eumelanin to pheomelanin. Although ASIP is not part of a larger protein complex its interaction with the MC1R receptor greatly influences pigmentation phenotypes.

Pathways

ASIP integrates into the melanocortin signaling pathway which regulates skin and hair color as well as energy expenditure. It interacts with key pathway proteins such as MC1R and α-MSH driving the balance between pigmentation and metabolic activity. ASIP’s role extends to pathways related to lipid metabolism linking it to proteins involved in energy balance and adiposity.

ASIP shows association with conditions such as obesity and melanoma. Its influence on energy homeostasis implicates it in the development of obesity where altered ASIP expression affects lipid storage and metabolism. ASIP’s interaction with MC1R also ties it to melanoma risk as changes in its activity might predispose individuals to pigmentation disorders influencing melanoma susceptibility. These interactions showcase ASIP’s connection to disease states through its modulation of receptor-related functions.
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Specifications

Form

Liquid

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General info

Function

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.

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Product protocols

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Target data

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
See full target information ASIP
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Product promise

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