Recombinant Human ASPRV1 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ASPRV1 also known as aspartic peptidase retroviral-like 1 is a protein involved in the breakdown of proteins within the skin. It belongs to the peptidase family known for their role in proteolysis. ASPRV1 has a molecular mass of approximately 47 kDa. This protein is expressed mainly in the upper layers of the epidermis which is the outermost part of the skin and is involved in epidermal differentiation.

Biological function summary

ASPRV1 facilitates the degradation of filaggrin an important protein required for skin hydration and barrier function. ASPRV1's activity is significant in the process of cornification an essential step in forming the skin barrier. It does not typically form part of a complex but acts independently to cleave specific protein substrates during epidermal differentiation. Proper functioning of ASPRV1 ensures the maintenance of healthy skin structure and hydration.

Pathways

ASPRV1 plays a critical role in the keratinocyte differentiation pathway. This pathway's importance lies in the skin's ability to form a protective barrier. ASPRV1 is related to filaggrin and other proteins involved in skin differentiation such as keratin. It assists in the regular turnover of epidermal cells by proteolytic processing of skin-specific proteins.

ASPRV1 connects to ichthyosis vulgaris and potentially atopic dermatitis due to its role in filaggrin processing. Disruption in ASPRV1 function can lead to impaired skin barrier and hydration contributing to these conditions. Filaggrin mutations are well-documented in ichthyosis vulgaris and ASPRV1's role in filaggrin breakdown makes it a point of interest. Further research continues to explore ASPRV1's influence on these skin disorders and its potential as therapeutic target.